Beaman M, Howie A J, Hardwicke J, Michael J, Adu D
Clin Nephrol. 1987 May;27(5):217-21.
The glomerular tip nephropathy is a cause of the nephrotic syndrome and has distinct pathological features. Glomerular tufts appear normal on light microscopy except for a segmental lesion invariably present in all glomeruli at the origin of the proximal tubule. Data on twenty adults whose renal biopsies demonstrated this lesion and who were followed for a mean of 7.4 years are analyzed. Eighteen patients were treated with steroids; ten of these had complete remission of proteinuria and seven a significant reduction of their proteinuria. Ten patients had moderately impaired renal function (serum creatinine greater than 120 mumol/l) at presentation, eight received steroids and achieved a reduction in serum creatinine. The prognosis was good, with no patient developing chronic renal failure requiring dialysis.
肾小球顶端肾病是肾病综合征的一个病因，具有独特的病理特征。在光学显微镜下，肾小球簇外观正常，只是在近端小管起始处的所有肾小球中均存在一个节段性病变。对20例肾活检显示有此病变且平均随访7.4年的成年人的数据进行了分析。18例患者接受了类固醇治疗；其中10例蛋白尿完全缓解，7例蛋白尿显著减少。10例患者在就诊时肾功能中度受损（血清肌酐大于120μmol/L），8例接受了类固醇治疗，血清肌酐有所降低。预后良好，没有患者发展为需要透析的慢性肾衰竭。
