Almog C, Isakov A, Ayalon D, Burke M, Shapira I
Clin Cardiol. 1987 May;10(5):347-9. doi: 10.1002/clc.4960100510.
Myoglobin, an oxygen-binding protein, is synthesized exclusively in striated and cardiac muscle, and is normally found in blood. Serum myoglobin determination has been used in the diagnosis of acute myocardial infarction. Experimental work has shown that myoglobin is released only after muscular necrosis. This prospective study included 101 patients: 62 with acute coronary insufficiency, 16 with acute myocardial infarction, and 23 controls. In all the patients with infarction the serum myoglobin levels were elevated. None of the controls showed serum myoglobin above normal. In patients with coronary insufficiency the peak serum myoglobin ranged from normal to 280 ng/ml. Half of all the patients with coronary insufficiency had a significant elevation of serum myoglobin (p less than 0.001). The obvious explanation of this finding is that myocardial necrosis to some extent develops in cases of so-called coronary insufficiency. Furthermore, this study confirms previous findings that serum myoglobin assessment constitutes a very early marker of myocardial damage.
肌红蛋白是一种氧结合蛋白，仅在横纹肌和心肌中合成，通常存在于血液中。血清肌红蛋白测定已用于急性心肌梗死的诊断。实验研究表明，肌红蛋白仅在肌肉坏死后才会释放。这项前瞻性研究纳入了101例患者：62例急性冠状动脉供血不足患者、16例急性心肌梗死患者和23例对照。所有梗死患者的血清肌红蛋白水平均升高。对照组中无一例血清肌红蛋白高于正常水平。冠状动脉供血不足患者的血清肌红蛋白峰值范围从正常到280纳克/毫升。所有冠状动脉供血不足患者中有一半血清肌红蛋白显著升高（p小于0.001）。这一发现的明显解释是，在所谓的冠状动脉供血不足病例中，在某种程度上会发生心肌坏死。此外，这项研究证实了先前的发现，即血清肌红蛋白评估是心肌损伤的一个非常早期的标志物。
