Feng Run-Lin, Tao Yan-Ping, Tan Zhi-Yong, Fu Shi, Wang Hai-Feng
Department of Pathology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China.
Department of Emergency, Kunming Third People's Hospital, Kunming 650000, Yunnan Province, China.
World J Clin Cases. 2022 Jun 26;10(18):6009-6020. doi: 10.12998/wjcc.v10.i18.6009.
Although sclerosing adenopathy of the prostate is a very rare benign disease, an effective differential diagnosis is required. Here, we report the clinicopathological and immunohistochemical morphological features of 12 cases of sclerosing adenopathy of the prostate to improve understanding of the disease.
To investigate the clinicopathological features, diagnosis, and immunohistochemical phenotypes that distinguish prostate sclerosing adenopathy from other conditions.
The clinical data, laboratory tests, pathological morphology, and immunohistochemical phenotypes of 12 cases of prostatic sclerosing adenopathy were retrospectively analyzed, and the relevant literature was reviewed.
All patients were elderly men (mean age, 71.7 years; 62-83 years). Eleven of them had hematuria, urinary frequency, urinary urgency, difficulty in urination, and serum total prostate-specific antigen values within the normal range. One patient had increased blood pressure. Enlarged prostates with single to multiple calcifying foci were observed. Moreover, prostate tissue hyperplastic changes were observed in all patients. Small follicular hyperplastic nodules without an obvious envelope, with a growth pattern mimicking the infiltration pattern of "prostate adenocarcinoma" were noted. Basal cells expressed AR, CKH, P63, and CK5/6, and myoepithelial markers, such as calponin, S100, and smooth muscle actin. No recurrence or exacerbation of the lesions was observed, except for one case of death due to bladder cancer.
Prostatic sclerosing adenopathy is highly misdiagnosed as prostate adenocarcinoma or other tumor-like lesions. Therefore, it should attract the attention of clinicopathologic researchers.
尽管前列腺硬化性腺病是一种非常罕见的良性疾病，但仍需要进行有效的鉴别诊断。在此，我们报告12例前列腺硬化性腺病的临床病理及免疫组化形态学特征，以提高对该疾病的认识。
探讨前列腺硬化性腺病的临床病理特征、诊断方法以及可将其与其他疾病相鉴别的免疫组化表型。
回顾性分析12例前列腺硬化性腺病患者的临床资料、实验室检查、病理形态及免疫组化表型，并复习相关文献。
所有患者均为老年男性（平均年龄71.7岁；年龄范围62 - 83岁）。其中11例有血尿、尿频、尿急、排尿困难，血清总前列腺特异性抗原值在正常范围内。1例患者血压升高。观察到前列腺增大，伴有单个至多个钙化灶；此外，所有患者均观察到前列腺组织增生性改变。发现有小的滤泡样增生结节，无明显包膜，其生长方式类似“前列腺腺癌”的浸润模式。基底细胞表达AR、CKH、P63和CK5/6以及肌上皮标志物，如钙调蛋白、S100和平滑肌肌动蛋白。除1例因膀胱癌死亡外，未观察到病变复发或加重。
前列腺硬化性腺病极易被误诊为前列腺腺癌或其他肿瘤样病变。因此，它应引起临床病理研究人员的关注。
