Grochowska Klaudia, Przeliorz Anna
Students' Research Group at the Department of Dietetics, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, Poland.
Department of Dietetics, Faculty of Pharmacy, Wroclaw Medical University, Wrocław, Poland.
Dement Geriatr Cogn Dis Extra. 2022 May 30;12(2):100-106. doi: 10.1159/000524331. eCollection 2022 May-Aug.
The ketogenic diet (KD) is a high-fat and low-carbohydrate diet with controlled amounts of protein. The use of drastic caloric restriction or ultralow-carbohydrate diets increases the production of ketone bodies, which are an alternative energy substrate in situations of insufficient glucose supply. Alzheimer's disease (AD) and Parkinson's disease are the most common neurodegenerative diseases in the world. It is believed that carbohydrate metabolism disorders may affect the progression of these diseases, as confirmed by both animal and human studies. Among patients with AD, the presence of ketone bodies in the body can improve cerebral circulation. Among Parkinson's patients, the presence of ketone bodies can reduce muscle tremor and stiffness, as well as improve cognitive function. The results of the research indicate that using a low-carbohydrate diet, including a KD, may have a beneficial effect on brain function in diseases that cause neuronal damage.
生酮饮食（KD）是一种高脂肪、低碳水化合物且蛋白质含量受控的饮食。采用严格的热量限制或极低碳水化合物饮食会增加酮体的生成，在葡萄糖供应不足的情况下，酮体是一种替代能量底物。阿尔茨海默病（AD）和帕金森病是世界上最常见的神经退行性疾病。动物和人体研究均证实，碳水化合物代谢紊乱可能会影响这些疾病的进展。在AD患者中，体内酮体的存在可改善脑循环。在帕金森病患者中，酮体的存在可减轻肌肉震颤和僵硬，并改善认知功能。研究结果表明，采用包括KD在内的低碳水化合物饮食可能对导致神经元损伤的疾病中的脑功能产生有益影响。
