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斑马鱼Klf11b通过抑制p53介导的细胞凋亡来维持细胞活力。

Zebrafish Klf11b is Required to Maintain Cell Viability by Inhibiting p53-Mediated Apoptosis.

作者信息

Kong Hee Jeong, Lee Jung Jin, Kim Ju-Won, Kim Julan, Kim Young-Ok, Yeo Sang-Yeob

机构信息

Biotechnology Research Division, National Institute of Fisheries Science, Busan 46083, Korea.

Dept. of Chemical and Biological Engineering, Hanbat National University, Daejeon 34158, Korea.

出版信息

Dev Reprod. 2022 Jun;26(2):79-90. doi: 10.12717/DR.2022.26.2.79. Epub 2022 Jun 30.

DOI:10.12717/DR.2022.26.2.79
PMID:35950165
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9336215/
Abstract

Krüppel-like factor 10 (KLF10) regulates various cellular functions, such as proliferation, differentiation and apoptosis, as well as the homeostasis of several types of tissue. In the present study, we attempted a loss-of-function analysis of zebrafish and , which constitute human KLF10 homologs. Embryos injected with () showed developmental retardation and cell death, whereas -injected embryos showed normal development. In -injected embryos, a dramatic increase in the amount of zebrafish mRNA might be the cause of the increase in that of . The degree of apoptosis decreased in the and co-injected embryos. These findings imply that KLF10 is a negative regulator of p53-dependent transcription, suggesting that the KLF10/p53 complex may play an important role in apoptosis for maintenance of tissue homeostasis during embryonic development.

摘要

Krüppel样因子10（KLF10）调节多种细胞功能，如增殖、分化和凋亡，以及几种组织类型的内环境稳定。在本研究中，我们对构成人类KLF10同源物的斑马鱼和进行了功能丧失分析。注射了（）的胚胎表现出发育迟缓及细胞死亡，而注射了的胚胎发育正常。在注射了的胚胎中，斑马鱼mRNA量的显著增加可能是的增加的原因。在同时注射了和的胚胎中，凋亡程度降低。这些发现表明KLF10是p53依赖性转录的负调节因子，提示KLF10/p53复合物可能在胚胎发育过程中维持组织内环境稳定的凋亡中起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46b4/9336215/e6f69a42cced/dr-26-2-79-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46b4/9336215/e53643cf2670/dr-26-2-79-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46b4/9336215/d9d493562658/dr-26-2-79-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46b4/9336215/9466065edb9e/dr-26-2-79-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46b4/9336215/fe65fd547895/dr-26-2-79-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46b4/9336215/e6f69a42cced/dr-26-2-79-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46b4/9336215/e53643cf2670/dr-26-2-79-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46b4/9336215/d9d493562658/dr-26-2-79-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46b4/9336215/9466065edb9e/dr-26-2-79-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46b4/9336215/fe65fd547895/dr-26-2-79-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46b4/9336215/e6f69a42cced/dr-26-2-79-g5.jpg

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Cell Rep. 2016 Mar 22;14(11):2528-37. doi: 10.1016/j.celrep.2016.02.049. Epub 2016 Mar 10.
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Genome-wide analysis of the zebrafish Klf family identifies two genes important for erythroid maturation.斑马鱼Klf家族的全基因组分析鉴定出两个对红细胞成熟很重要的基因。
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Krüppel-like factor 10 null mice exhibit lower tumor incidence and suppressed cellular proliferation activity following chemically induced liver tumorigenesis.
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