Diagnosis of leptomeningeal metastasis.

Forty-one cases of leptomeningeal metastases from solid and hematological tumours were studied clinically and pathologically. Neurological symptoms and signs, cerebrospinal fluid characteristics and radiographic appearance were reviewed. The role of the biochemical markers, computer tomography scans of the brain and myelography in the diagnosis of patients with leptomeningeal metastasis were determined. The subject of the study was an investigation of the value of various diagnostic procedures to increase the accuracy of the diagnosis leptomeningeal metastasis.