Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Institute of Science, Technology and Humanities of Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Clin Exp Optom. 2023 Jul;106(5):455-465. doi: 10.1080/08164622.2022.2106779. Epub 2022 Aug 11.
Dry eye has become an increasingly prevalent public health issue for which there is currently no cure. Manuka honey possesses anti-inflammatory and antioxidant properties that can be used to treat dry eye. The present study aimed to systematically review evidence supporting the treatment of dry eye with manuka honey and quantify this evidence via meta-analysis. Randomised clinical trials that fulfilled the inclusion criteria from database inception until 5 September 2021, were identified through online searches of seven databases, including but not limited to Embase, Medline, and Central. Changes between the point of longest follow-up and baseline subjective symptoms, tear film quality, ocular surface characteristics, adverse events, and compliance were selected for meta-analysis. A total of 288 adult participants with dry eye from five eligible randomised controlled trials were analysed. Compared with the control groups, treatment with manuka honey demonstrated a significant improvement in Ocular Surface Disease Index, Standard Patient Evaluation of Eye Dryness, tear evaporation rate, negative conversion rate of matrix metalloproteinase-9 levels, ocular surface staining, and daily use frequency of lubricant. No serious adverse events were reported, except for temporary stinging and redness, which were generally tolerated. This review found that manuka honey demonstrated promising results for the treatment of dry eye. However, limitations of the included studies and analytical methodology affect the reliability of this conclusion. Therefore, further high-quality randomised clinical trials are required to confirm the efficacy and safety of the use of manuka honey in the treatment of dry eye.
干眼症已成为日益普遍的公共卫生问题，但目前尚无治愈方法。麦卢卡蜂蜜具有抗炎和抗氧化特性，可用于治疗干眼症。本研究旨在系统回顾支持麦卢卡蜂蜜治疗干眼症的证据，并通过荟萃分析对该证据进行量化。通过对包括 Embase、Medline 和 Central 在内的七个数据库进行在线搜索，确定了从数据库建立之初到 2021 年 9 月 5 日符合纳入标准的随机临床试验。选择最长随访时间点与基线主观症状、泪膜质量、眼表特征、不良反应和依从性的变化进行荟萃分析。对五项合格的随机对照试验中 288 名干眼症成年参与者进行了分析。与对照组相比，麦卢卡蜂蜜治疗组在眼表疾病指数、标准患者眼干评估、泪蒸发率、基质金属蛋白酶-9 水平的阴性转化率、眼表染色和润滑剂每日使用频率方面均有显著改善。除暂时刺痛和发红外，未报告严重不良事件，通常可耐受。本综述发现，麦卢卡蜂蜜在治疗干眼症方面显示出良好的效果。然而，纳入研究的局限性和分析方法学影响了这一结论的可靠性。因此，需要进一步的高质量随机临床试验来证实麦卢卡蜂蜜治疗干眼症的疗效和安全性。
