牛肾上腺髓质和血小板中琥珀酸半醛脱氢酶活性：与脑酶的比较研究

Succinic semialdehyde dehydrogenase activity in bovine adrenal medulla and blood platelets: a comparative study with the brain enzyme.

作者信息

González M P, Oset-Gasque M J, Gimenez Solves A, Cañadas S

出版信息

Comp Biochem Physiol B. 1987;86(3):489-92. doi: 10.1016/0305-0491(87)90436-6.

Abstract

In the present paper we report the presence of succinic semialdehyde dehydrogenase (SSADH) in bovine adrenal medulla and blood platelets. Both enzymes present some analogies with the brain enzyme in terms of cofactor requirements, optimal pH, mitochondrial localizaton and inhibition by AMP. However, the activity of the platelet enzyme is 100 times lower than that of the brain and affinities of both enzymes for their specific substrate succinic semialdehyde and NAD are different. The presence of SSADH in adrenal medulla and blood platelets allows us to confirm the presence of a complete GABA bypass in these tissues, where the neurotransmitter could have important regulator functions.

摘要

在本论文中，我们报告了在牛肾上腺髓质和血小板中存在琥珀酸半醛脱氢酶（SSADH）。这两种酶在辅因子需求、最适pH值、线粒体定位以及被AMP抑制方面与脑内的酶存在一些相似之处。然而，血小板中该酶的活性比脑内的低100倍，并且这两种酶对其特定底物琥珀酸半醛和NAD的亲和力也不同。肾上腺髓质和血小板中存在SSADH，这使我们能够确认在这些组织中存在完整的γ-氨基丁酸旁路，在这些组织中神经递质可能具有重要的调节功能。