一种复方草药 AYUSH 制剂治疗 SARS-CoV-2 疾病的康复率和症状疗效：一项单臂试验。

Rate of Recovery and Symptomatic Efficacy of a Polyherbal AYUSH Formulation in the Treatment of SARS-CoV-2 Disease: A Single-arm Trial.

出版信息

Altern Ther Health Med. 2023 May;29(4):134-139.

Abstract

BACKGROUND

The COVID-19 pandemic, caused by the human coronavirus, SARS-CoV-2, has led to the death of millions across the globe. The SARS-CoV-2 virus is highly infectious, and mutates rapidly. This creates additional challenges for the development of robust therapeutic solutions. Along with modern healthcare, there is a need to explore natural, plant-based antiviral compounds that can be used in the treatment of COVID-19.

OBJECTIVE

The present feasibility study investigates the efficacy of a 13-ingredient Ayurvedic polyherbal formulation, NOQ19, in the management of COVID-19.

METHODOLOGY

A single-arm, open-label study design was adopted for this feasibility study. 161 RT-PCR-positive COVID-19 patients were enrolled. The enrolled participants were provided with the Ayurvedic intervention - two tablets of NOQ19 thrice daily along with the standard of care treatment. Follow-up COVID-19 RT-PCR tests were conducted on days 5, 10, and 14 or until the patient tested negative. The time taken to turn RT-PCR negative or become asymptomatic was noted.

SETTING

The study was conducted at Sri Sri Institute for Advanced Research from April 2021 to June 2021.

PARTICIPANTS

A total of 161 COVID-19 patients isolating at home were assessed.

INTERVENTION

The NOQ19 preparation is a combination of 13 Ayurvedic herbs.

OUTCOMES MEASURED

RT-PCR tests, the turnaround time to becoming asymptomatic, and regular symptoms assessment.

RESULTS

The analysis demonstrated that 74% of the patients tested negative on the RT-PCR within five days of taking NOQ19. Additionally, 98% of the subjects tested negative on the RT-PCR on day 10 after taking NOQ19 and standard of care treatment (as necessary). None of the participants reported any adverse events or side-effects due to NOQ19 medication.

CONCLUSION

The NOQ19 Ayurvedic polyherbal formulation can be an effective and safe option for the symptomatic management of COVID-19.

摘要

背景

由人类冠状病毒 SARS-CoV-2 引起的 COVID-19 大流行已导致全球数百万人死亡。SARS-CoV-2 病毒具有高度传染性，且迅速变异。这为开发强大的治疗方法带来了额外的挑战。除了现代医疗保健，还需要探索可用于治疗 COVID-19 的天然植物类抗病毒化合物。

目的

本可行性研究调查了一种由 13 种成分组成的阿育吠陀复方草药配方 NOQ19 在 COVID-19 管理中的疗效。

方法

本可行性研究采用单臂、开放标签研究设计。共招募了 161 名 RT-PCR 阳性 COVID-19 患者。为纳入的参与者提供了阿育吠陀干预措施-每天三次服用两片 NOQ19，同时接受标准护理治疗。在第 5、10 和 14 天或直到患者检测结果为阴性时进行 COVID-19 的 RT-PCR 随访检测。记录 RT-PCR 转为阴性或出现症状缓解的时间。