Hayakawa R, Matsunaga K, Suzuki M, Arima Y, Ohkido Y
Contact Dermatitis. 1987 Apr;16(4):215-9. doi: 10.1111/j.1600-0536.1987.tb01428.x.
An 18-year-old girl developed cheilitis. She had a past history of lip cream dermatitis, but the cause was not found. Patch tests with 2 lipsticks were strongly positive. Tests with the ingredients were positive to 2 aliphatic compounds, glyceryl diisostearate and diisostearyl malate. Impurities in the materials were suspected as the cause. Analysis by gas chromatography detected 3 chemicals in glyceryl diisostearate and 1 in diisostearyl malate as impurities. Patch testing with the impurities and glyceryl monoisostearate 0.01% pet in glyceryl diisostearate and isostearyl alcohol 0.25% pet in diisostearyl malate were strongly positive. The characteristics common to the 2 chemicals were liquidity at room temperature, branched C18 aliphatic compound and primary alcohol. Chemicals lacking any of the above 3 features did not react.
一名18岁女孩患了唇炎。她曾有唇膏性皮炎病史，但病因未查明。对2支口红进行斑贴试验呈强阳性。对其成分进行检测，结果显示对2种脂肪族化合物（二异硬脂酸甘油酯和苹果酸二异硬脂醇酯）呈阳性反应。怀疑材料中的杂质是病因。通过气相色谱分析，在二异硬脂酸甘油酯中检测到3种化学物质作为杂质，在苹果酸二异硬脂醇酯中检测到1种化学物质作为杂质。用这些杂质以及二异硬脂酸甘油酯中0.01%凡士林基质的单异硬脂酸甘油酯和苹果酸二异硬脂醇酯中0.25%凡士林基质的异硬脂醇进行斑贴试验，结果呈强阳性。这2种化学物质共有的特征是在室温下呈液态、具有支链的C18脂肪族化合物以及伯醇。缺乏上述3个特征中任何一个的化学物质均无反应。
