Enantioselective Formation of All-Carbon Quaternary Stereocenters in -Difluorinated Cyclopropanes via Rhodium-Catalyzed Stereoablative Kinetic Resolution.

Herein, we report an effective method to offer chiral -difluorinated cyclopropanes containing an all-carbon quaternary stereocenter by rhodium-catalyzed stereoablative kinetic resolution. The activation of a sterically hindered all-carbon quaternary C-C bond through oxidative addition with a chiral rhodium complex is proposed as the enantiodetermining step. A wide range of -difluorinated cyclopropanes can be obtained with excellent ee values (ee = 87% to >99.9%), which are demonstrated to be useful chiral fluorine-containing building blocks by a series of postfunctionalizations.