Eschenbacher W L, Gravelyn T R
Chest. 1987 Jul;92(1):105-9. doi: 10.1378/chest.92.1.105.
A novel technique has been developed for the isolation and lavaging of a central airway segment in humans. The procedure uses a double-balloon airway-sampling catheter that is placed into the airways with fiberoptic bronchoscopic guidance. A protocol using this technique was attempted in 32 subjects (18 normal subjects and 14 subjects with mild asthma), and 27 of the subjects were able to complete all phases of the protocol, including bronchoalveolar lavage and lavage of an isolated airway segment. There was no significant complication in any subject. Cellular composition of the lavages demonstrated differences in cell differential and total cell counts for the two different sampled regions (central airway vs alveolar spaces). We believe that this technique of lavage of an isolated airway segment is safe and has potential usefulness in many areas of pulmonary research.
一种用于分离和灌洗人体中央气道段的新技术已经研发出来。该程序使用一种双气囊气道采样导管，在纤维支气管镜引导下将其放置到气道中。在32名受试者（18名正常受试者和14名轻度哮喘受试者）中尝试了使用该技术的方案，其中27名受试者能够完成该方案的所有阶段，包括支气管肺泡灌洗和对孤立气道段的灌洗。任何受试者均未出现明显并发症。灌洗的细胞组成显示，两个不同采样区域（中央气道与肺泡腔）的细胞分类和总细胞计数存在差异。我们认为，这种孤立气道段灌洗技术是安全的，并且在肺部研究的许多领域具有潜在用途。
