School of Life and Environmental Sciences, University of Sydney, NSW 2006, Australia.
Sainsbury Laboratory, University of Cambridge, UK; Department of Applied Mathematics and Theoretical Physics, University of Cambridge, UK; Computational Biology and Biological Physics, Lund University, Sweden.
Curr Opin Plant Biol. 2022 Oct;69:102262. doi: 10.1016/j.pbi.2022.102262. Epub 2022 Aug 8.
Plant development is regulated by transcription factors that often act in more than one process and stage of development. Yet the molecular mechanisms that govern the functional diversity and specificity of these proteins remains far from understood. Flower development provides an ideal context to study these mechanisms since the development of distinct floral organs depends on similar but distinct combinations of transcriptional regulators. Recent work also highlights the importance of leaf polarity regulators as additional key factors in flower initiation, floral organ morphogenesis, and possibly floral organ positioning. A detailed understanding of how these factors work in combination will enable us to address outstanding questions in flower development including how distinct shapes and positions of floral organs are generated. Experimental approaches and computer-based modeling will be required to characterize gene-regulatory networks at the level of single cells.
植物的发育受转录因子调控，这些转录因子通常在多个发育过程和阶段中发挥作用。然而，这些蛋白质功能多样性和特异性的分子机制仍远未被理解。花的发育为研究这些机制提供了一个理想的背景，因为不同花器官的发育依赖于相似但不同的转录调控因子组合。最近的研究还强调了叶极性调控因子作为花起始、花器官形态发生以及可能的花器官定位的附加关键因素的重要性。详细了解这些因子如何组合工作将使我们能够解决花发育中的突出问题，包括如何产生不同形状和位置的花器官。需要实验方法和基于计算机的建模来在单细胞水平上描述基因调控网络。
