在雄性大鼠心肌梗死进展过程中心脏功能障碍和血液动力学损伤的相互作用。
The interplay of cardiac dysfunctions and hemodynamic impairments during the progression of myocardial infarction in male rats.
机构信息
Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, China.
Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, China; PKU-HKUST Shenzhen-Hong Kong Institution, Shenzhen, Guangdong, China; Shenzhen Graduate School, Peking University, Shenzhen, Guangdong, China; Shenzhen Bay Laboratory, Shenzhen, Guangdong, China.
出版信息
J Biomech. 2022 Sep;142:111237. doi: 10.1016/j.jbiomech.2022.111237. Epub 2022 Jul 30.
Myocardial infarction (MI) can induce heart failure with reduced ejection fraction (HFrEF). Systemic circulation is of importance to interact with MI-induced HFrEF. Hence, we studied the changes of myofiber stresses and peripheral hemodynamics during the progression from MI to HFrEF. MI was induced in Wistar male rats by the coronary artery ligation surgery. Physiological and hemodynamic measurements were carried out in the LV and peripheral arteries at postoperative 3 and 6 weeks, based on which LV myofiber stresses were computed and peripheral hemodynamic analysis was demonstrated. This study showed that MI significantly impaired cardiac functions and peripheral hemodynamics and altered the corresponding histological properties of cardiac wall and peripheral arterial wall, which deteriorated with time after operation. In summary, the interplay of cardiac dysfunctions and hemodynamic impairments accelerates the progression of MI-induced HF.
心肌梗死（MI）可引起射血分数降低的心力衰竭（HFrEF）。全身循环对于与 MI 引起的 HFrEF 相互作用很重要。因此，我们研究了从 MI 发展到 HFrEF 过程中心肌纤维应力和外周血液动力学的变化。通过冠状动脉结扎手术在 Wistar 雄性大鼠中诱导 MI。在术后 3 周和 6 周时，在 LV 和外周动脉中进行生理和血液动力学测量，根据这些测量值计算 LV 心肌纤维应力并展示外周血液动力学分析。这项研究表明，MI 显著损害了心脏功能和外周血液动力学，并改变了心脏壁和外周动脉壁的相应组织学特性，这些特性在手术后随时间恶化。总之，心脏功能障碍和血液动力学损害的相互作用加速了 MI 引起的 HF 的进展。
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