甲氧苄啶和磺胺嘧啶在急性胆囊炎时胆汁及胆囊中的渗透情况。

Trimethoprim and sulfadiazine penetration into bile and gallbladder in acute cholecystitis.

作者信息

Mattila J, Auvinen O, Hiltunen K M, Gordin A

出版信息

Chemotherapy. 1987;33(3):160-4. doi: 10.1159/000238489.

Abstract

The concentrations of trimethoprim (TMP) and sulfadiazine (SDZ) in serum, bile and gallbladder wall of 9 patients with acute cholecystitis were measured after b.i.d. treatment with 160 mg of TMP + 500 mg of SDZ. The samples were collected 2-4 h after the last dose. Mean TMP concentrations were 1.71 +/- (SE) 0.51 micrograms/ml, 4.53 +/- 5.26 micrograms/ml and 2.31 +/- micrograms/g in serum, bile and gallbladder, respectively. Mean SDZ concentrations were 22.2 +/- 14.9 micrograms/ml in serum, 9.37 +/- 8.99 micrograms/ml in bile and 16.1 +/- 10.1 micrograms/g in gallbladder. The average ratios of bile-serum and gallbladder-serum concentrations were 2.64 and 1.35 for TMP and 0.42 and 0.73 for SDZ. There was a significant correlation between serum and gallbladder concentrations of both TMP and SDZ. No correlation existed between serum and bile levels.

摘要

对9例急性胆囊炎患者采用每日2次、每次160mg甲氧苄啶（TMP）+500mg磺胺嘧啶（SDZ）治疗后，测定其血清、胆汁及胆囊壁中TMP和SDZ的浓度。在末次给药后2 - 4小时采集样本。血清、胆汁及胆囊中TMP的平均浓度分别为1.71±（标准误）0.51μg/ml、4.53±5.26μg/ml和2.31±μg/g。血清、胆汁及胆囊中SDZ的平均浓度分别为22.2±14.9μg/ml、9.37±8.99μg/ml和16.1±10.1μg/g。TMP的胆汁 - 血清及胆囊 - 血清浓度平均比值分别为2.64和1.35，SDZ的分别为0.42和0.73。TMP和SDZ的血清与胆囊浓度之间存在显著相关性。血清与胆汁水平之间无相关性。