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基于国家数据库数据探讨年龄对骨水泥型与非骨水泥型活动平台单髁膝关节置换相对疗效的影响

The Effect of Age on the Relative Outcomes of Cemented and Cementless Mobile-Bearing Unicompartmental Knee Arthroplasty, Based on Data From National Databases.

作者信息

Mohammad Hasan R, Judge Andrew, Murray David W

机构信息

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences University of Oxford, Nuffield Orthopaedic Centre, Oxford, United Kingdom; Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, Level 1 Learning and Research Building, Southmead Hospital, Bristol, United Kingdom; Barts Bone & Joint Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, United Kingdom.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences University of Oxford, Nuffield Orthopaedic Centre, Oxford, United Kingdom; Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, Level 1 Learning and Research Building, Southmead Hospital, Bristol, United Kingdom.

出版信息

J Arthroplasty. 2023 Jan;38(1):30-36.e1. doi: 10.1016/j.arth.2022.08.004. Epub 2022 Aug 8.

Abstract

BACKGROUND

Unicompartmental knee arthroplasty (UKA) is an effective treatment for medial compartment arthritis. A challenge is that patients requiring knee arthroplasty are becoming younger. It is currently unknown what the relative performances of cemented and cementless UKAs are, in different age groups.

METHODS

A total of 12,882 cemented and cementless UKAs from the National Joint Registry and Hospital Episodes Statistics databases were matched on patient and surgical factors. Patients were stratified into 3 groups: (1) <60 years; (2) 60-69 years; and (3) ≥70 years. Revision and reoperation rates were compared using Cox regression analyses.

RESULTS

The 10-year implant survival for the matched cemented and cementless UKAs for (1) <60 years were 81.4% (CI 73.6-87.0) and 86.7% (CI 80.7-90.9) (hazard ratio [HR] 0.73, CI 0.56-0.94, P = .02); (2) for 60-69 years were 91.8% (CI 88.9-94.0) and 94.5% (CI 92.9-95.7) (HR 0.90, CI 0.67-1.22, P = .51); and (3) ≥70 years were 93.5% (CI 91.1-95.3) and 94.2% (CI 92.0-95.8) (HR 1.0, CI 0.71-1.40, P = .99). The same trend was observed for reoperations. In the <60 years and 60-69 years groups there were significantly fewer revisions for aseptic loosening in the cementless group (0.5% versus 1.6% [P < .001] and 0.4% versus 1.3% [P = .002], respectively).

CONCLUSION

Younger ages were associated with higher revision rates in both cemented and cementless UKA groups. Cementless fixation has reduced long-term revision rates compared to cemented fixation in the <60 years group with aseptic loosening rates 3 times lower.

LEVEL OF EVIDENCE

III.

摘要

背景

单髁膝关节置换术(UKA)是治疗内侧间室关节炎的有效方法。一个挑战是,需要进行膝关节置换术的患者正变得越来越年轻。目前尚不清楚骨水泥型和非骨水泥型UKA在不同年龄组中的相对性能如何。

方法

从国家关节注册中心和医院病历统计数据库中选取了总共12882例骨水泥型和非骨水泥型UKA,并根据患者和手术因素进行匹配。患者被分为3组:(1)<60岁;(2)60 - 69岁;(3)≥70岁。使用Cox回归分析比较翻修率和再次手术率。

结果

匹配的骨水泥型和非骨水泥型UKA在(1)<60岁组的10年植入物生存率分别为81.4%(95%CI 73.6 - 87.0)和86.7%(95%CI 80.7 - 90.9)(风险比[HR] 0.73,95%CI 0.56 - 0.94,P = 0.02);(2)60 - 69岁组分别为91.8%(95%CI 88.9 - 94.0)和94.5%(95%CI 92.9 - 95.7)(HR 0.90,95%CI 0.67 - 1.22,P = 0.51);(3)≥70岁组分别为93.5%(95%CI 91.1 - 95.3)和94.2%(95%CI 92.0 - 95.8)(HR 1.0,95%CI 0.71 - 1.40,P = 0.99)。再次手术也观察到相同趋势。在<60岁和60 - 69岁组中,非骨水泥组因无菌性松动导致的翻修明显较少(分别为0.5%对1.6%[P < 0.001]和0.4%对1.3%[P = 0.002])。

结论

在骨水泥型和非骨水泥型UKA组中,年龄较小与较高的翻修率相关。与骨水泥固定相比,非骨水泥固定在<60岁组降低了长期翻修率,无菌性松动率降低了3倍。

证据级别

III级

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