Kumar Rahul, Thakur Amit K, Banerjee Nilanjana, Kumar Ashutosh, Gaurav Gajendra Kumar, Arya Raj Kumar
Department of Chemical Engineering, Energy Cluster, University of Petroleum and Energy Studies, Dehradun, 248007, Uttarakhand, India.
Department of Chemical Engineering, Indian Institute of Technology Delhi, 110016, New Delhi, India.
Drug Deliv Transl Res. 2023 Feb;13(2):400-418. doi: 10.1007/s13346-022-01219-1. Epub 2022 Aug 11.
The present work reviews the liquid antisolvent crystallization (LASC) to prepare the nanoparticle of pharmaceutical compounds to enhance their solubility, dissolution rate, and bioavailability. The application of ultrasound and additives is discussed to prepare the particles with narrow size distribution. The use of ionic liquid as an alternative to conventional organic solvent is presented. Herbal compounds, also known for low aqueous solubility and limited clinical application, have been crystalized by LASC and discussed here. The particle characteristics such as particle size and particle size distribution are interpreted in terms of supersaturation, nucleation, and growth phenomena. To overcome the disadvantage of batch crystallization, the scientific literature on continuous flow reactors is also reviewed. LASC in a microfluidic device is emerging as a promising technique. The different design of the microfluidic device and their application in LASC are discussed. The combination of the LASC technique with traditional techniques such as high-pressure homogenization and spray drying is presented. A comparison of product characteristics prepared by LASC and the supercritical CO antisolvent method is discussed to show that LASC is an attractive and inexpensive alternative for nanoparticle preparation. One of the major strengths of this paper is a discussion on less-explored applications of LASC in pharmaceutical research to attract the attention of future researchers.
本工作综述了液相抗溶剂结晶法（LASC）制备药物化合物纳米颗粒以提高其溶解度、溶解速率和生物利用度的情况。讨论了超声和添加剂在制备窄粒度分布颗粒方面的应用。介绍了使用离子液体替代传统有机溶剂的情况。溶解度低且临床应用有限的草药化合物也已通过LASC结晶并在此进行了讨论。从过饱和度、成核和生长现象的角度解释了颗粒特性，如粒径和粒度分布。为克服间歇结晶的缺点，还综述了关于连续流动反应器的科学文献。微流控装置中的LASC正成为一种有前景的技术。讨论了微流控装置的不同设计及其在LASC中的应用。介绍了LASC技术与高压均质化和喷雾干燥等传统技术的结合。讨论了通过LASC和超临界CO₂抗溶剂法制备的产品特性比较，以表明LASC是制备纳米颗粒的一种有吸引力且廉价的替代方法。本文的一大优势是讨论了LASC在药物研究中较少被探索的应用，以吸引未来研究人员的关注。
