Hai Yu, Kawachi Asuka, He Xiaodong, Yoshimi Akihide
Cancer RNA Research Unit, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
Department of Physical and Chemical Inspection, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Cancers (Basel). 2022 Aug 5;14(15):3812. doi: 10.3390/cancers14153812.
RNA-binding proteins (RBPs) are proteins that physically and functionally bind to RNA to regulate the RNA metabolism such as alternative splicing, polyadenylation, transport, maintenance of stability, localization, and translation. There is accumulating evidence that dysregulated RBPs play an essential role in the pathogenesis of malignant tumors including a variety of types of sarcomas. On the other hand, prognosis of patients with sarcoma, especially with sarcoma in advanced stages, is very poor, and almost no effective standard treatment has been established for most of types of sarcomas so far, highlighting the urgent need for identifying novel therapeutic targets based on the deep understanding of pathogenesis. Therefore, defining the network of interactions between RBPs and disease-related RNA targets will contribute to a better understanding of sarcomagenesis and identification of a novel therapeutic target for sarcomas.
RNA结合蛋白（RBPs）是一类能在物理和功能上与RNA结合，从而调节RNA代谢的蛋白质，如可变剪接、多聚腺苷酸化、转运、稳定性维持、定位和翻译等过程。越来越多的证据表明，失调的RBPs在包括多种类型肉瘤在内的恶性肿瘤发病机制中起着至关重要的作用。另一方面，肉瘤患者，尤其是晚期肉瘤患者的预后非常差，到目前为止，大多数类型的肉瘤几乎没有建立有效的标准治疗方法，这凸显了基于对发病机制的深入理解来确定新治疗靶点的迫切需求。因此，确定RBPs与疾病相关RNA靶点之间的相互作用网络，将有助于更好地理解肉瘤的发生机制，并为肉瘤确定新的治疗靶点。
