Albano Domenico, Dondi Francesco, Bertagna Francesco, Treglia Giorgio
Nuclear Medicine Department, ASST Spedali Civili Brescia, 25126 Brescia, Italy.
Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, Nuclear Medicine, University of Brescia, 25121 Brescia, Italy.
Cancers (Basel). 2022 Aug 5;14(15):3814. doi: 10.3390/cancers14153814.
The aim of this systematic review was to investigate published data about the role of gallium-68 Pentixafor positron emission tomography/computed tomography ([Ga]Ga-Pentixafor PET/CT) or PET/magnetic resonance imaging (PET/MRI) in patients affected by lymphoma. A comprehensive computer literature search of the Scopus, PubMed/MEDLINE, and Embase databases was conducted including articles indexed up to June 2022. In total, 14 studies or subsets in studies were eligible for inclusion. From the analyses of the selected studies, the following main findings have been found: (1) lymphomas can be considered [Ga]Ga-Pentixafor avid diseases, also in cases of fluorine-18 fluorodeoxyglucose [F]FDG-not avid forms such as lymphoplasmacytic lymphoma (LPL), chronic lymphocytic leukemia (CLL), marginal zone lymphoma (MZL) and central nervous system lymphoma (CNSL); (2) among lymphomas, mantle cell lymphoma (MCL) and MZL are those with highest [Ga]Ga-Pentixafor uptake; (3) [Ga]Ga-Pentixafor PET/CT or PET/MRI is a useful tool for the staging and treatment response evaluation; (4) [Ga]Ga-Pentixafor PET seems to have a better diagnostic performance than [F]FDG PET in evaluating lymphomas. Despite several limitations affecting this analysis, especially related to the heterogeneity of the included studies, [Ga]Ga-Pentixafor PET may be considered a useful imaging method for staging and treatment response evaluation of several lymphomas, especially MZL, CNSL and LPL.
本系统评价的目的是调查已发表的关于镓-68 喷替沙福正电子发射断层扫描/计算机断层扫描（[Ga]Ga-喷替沙福PET/CT）或PET/磁共振成像（PET/MRI）在淋巴瘤患者中的作用的数据。对Scopus、PubMed/MEDLINE和Embase数据库进行了全面的计算机文献检索，纳入截至2022年6月索引的文章。总共14项研究或研究中的子集符合纳入标准。通过对所选研究的分析，发现了以下主要结果：（1）淋巴瘤可被视为[Ga]Ga-喷替沙福摄取活跃的疾病，即使在氟-18氟脱氧葡萄糖[F]FDG摄取不活跃的形式中，如淋巴浆细胞淋巴瘤（LPL）、慢性淋巴细胞白血病（CLL）、边缘区淋巴瘤（MZL）和中枢神经系统淋巴瘤（CNSL）；（2）在淋巴瘤中，套细胞淋巴瘤（MCL）和MZL是[Ga]Ga-喷替沙福摄取最高的；（3）[Ga]Ga-喷替沙福PET/CT或PET/MRI是分期和治疗反应评估的有用工具；（4）在评估淋巴瘤方面，[Ga]Ga-喷替沙福PET似乎比[F]FDG PET具有更好的诊断性能。尽管该分析存在一些局限性，尤其是与纳入研究的异质性有关，但[Ga]Ga-喷替沙福PET可被视为几种淋巴瘤分期和治疗反应评估的有用成像方法，尤其是MZL、CNSL和LPL。
