Qing Furong, Xie Tao, Xie Lu, Guo Tianfu, Liu Zhiping
Center for Immunology, Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, China.
School of Graduate, Gannan Medical University, Ganzhou 341000, China.
Cancers (Basel). 2022 Aug 6;14(15):3821. doi: 10.3390/cancers14153821.
Disorders of gut microbiota have been closely linked to the occurrence of various intestinal diseases including colitis and colorectal cancer (CRC). Specifically, the production of beneficial bacteria and intestinal metabolites may slow the development of some intestinal diseases. Recently, it has been proposed that pattern recognition receptors (PRRs) not only recognize pathogens and initiate inflammatory signal transduction to induce immune responses but also influence the composition of intestinal microorganisms. However, the mechanisms through which PRRs regulate gut microbiota in the setting of colitis and CRC have rarely been systematically reviewed. Therefore, in this paper, we summarize recent advances in our understanding of how PRRs shape gut microbiota and how this influences the development of colitis and CRC.
肠道微生物群紊乱与包括结肠炎和结直肠癌（CRC）在内的各种肠道疾病的发生密切相关。具体而言，有益细菌和肠道代谢产物的产生可能会减缓某些肠道疾病的发展。最近，有人提出模式识别受体（PRRs）不仅能识别病原体并启动炎症信号转导以诱导免疫反应，还会影响肠道微生物的组成。然而，在结肠炎和结直肠癌背景下PRRs调节肠道微生物群的机制很少得到系统综述。因此，在本文中，我们总结了我们对PRRs如何塑造肠道微生物群以及这如何影响结肠炎和结直肠癌发展的最新认识进展。
