Morales C, Griswold M D
Endocrinology. 1987 Jul;121(1):432-4. doi: 10.1210/endo-121-1-432.
Vitamin A deficiency (VAD) in rats causes a progressive germ cell depletion and cessation of spermatogenesis resulting in seminiferous tubules which contain only Sertoli cells, spermatogonia and a small number of preleptotene spermatocytes. Spermatogenesis can be rapidly restored by the administration of retinol. Our preliminary studies suggested a partial stage synchronization of many seminiferous tubules in VAD male rats subsequently treated with retinol. To confirm this observation and to achieve a better synchronization, VAD rats received 2 SC injections of retinol suspended in sesame oil followed by daily oral administrations of 0.5 mg of retinol. In all rats an almost perfect synchronous stage development of seminiferous tubules evolved in a predictable manner and was maintained through 2 spermiations.
大鼠维生素A缺乏（VAD）会导致生殖细胞逐渐耗竭和精子发生停止，从而使生精小管中仅含有支持细胞、精原细胞和少量前细线期精母细胞。通过给予视黄醇可迅速恢复精子发生。我们的初步研究表明，在随后用视黄醇治疗的VAD雄性大鼠中，许多生精小管存在部分阶段同步化。为了证实这一观察结果并实现更好的同步化，VAD大鼠接受了2次皮下注射悬浮于芝麻油中的视黄醇，随后每天口服0.5 mg视黄醇。在所有大鼠中，生精小管几乎完美的同步阶段发育以可预测的方式演变，并持续经历2次精子排放。
