Unidad de Investigación, Instituto de Investigación e Innovación en Ciencias Biomédicas de la Provincia de Cádiz (INiBICA), 11009 Cádiz, Spain.
Departamento de Endocrinología y Nutrición, Hospital Universitario Puerta del Mar, Universidad de Cádiz, 11009 Cádiz, Spain.
Int J Mol Sci. 2022 Jul 30;23(15):8450. doi: 10.3390/ijms23158450.
Inflammatory processes play a central role in the pathogenesis of diabetic nephropathy (DN) in the early stages of the disease. The authors demonstrate that the glycolipid mimetic ()-DS-ONJ is able to abolish inflammation via the induction of autophagy flux and provokes the inhibition of inflammasome complex in ex vivo and in vitro models, using adult kidney explants from BB rats. The contribution of ()-DS-ONJ to reducing inflammatory events is mediated by the inhibition of classical stress kinase pathways and the blocking of inflammasome complex activation. The (-DS-ONJ treatment is able to inhibit the epithelial-to-mesenchymal transition (EMT) progression, but only when the IL18 levels are reduced by the treatment. These findings suggest that ()-DS-ONJ could be a novel, and multifactorial treatment for DN.
在疾病早期，炎症过程在糖尿病肾病 (DN) 的发病机制中起核心作用。作者证明，糖脂类似物 ()-DS-ONJ 通过诱导自噬通量来消除炎症，并在 BB 大鼠的成年肾外植体的离体和体外模型中引发炎症小体复合物的抑制。()-DS-ONJ 减少炎症事件的贡献是通过抑制经典应激激酶途径和阻断炎症小体复合物激活来介导的。(-DS-ONJ 治疗能够抑制上皮间质转化 (EMT) 的进展，但只有在通过治疗降低 IL18 水平时才会发生这种情况。这些发现表明 ()-DS-ONJ 可能是一种新的、多因素的 DN 治疗方法。
