Laboratory of Molecular Genetics of Aging and Tumor, Medical School, Kunming University of Science and Technology, 727 South Jing Ming Road, Kunming 650500, China.
Int J Mol Sci. 2022 Aug 4;23(15):8689. doi: 10.3390/ijms23158689.
The complement system is a part of the immune system and consists of multiple complement components with biological functions such as defense against pathogens and immunomodulation. The complement system has three activation pathways: the classical pathway, the lectin pathway, and the alternative pathway. Increasing evidence indicates that the complement system plays a role in aging. Complement plays a role in inflammatory processes, metabolism, apoptosis, mitochondrial function, and Wnt signaling pathways. In addition, the complement system plays a significant role in aging-related diseases, including Alzheimer's disease, age-related macular degeneration, and osteoarthritis. However, the effect of complement on aging and aging-related diseases is still unclear. Thus, a better understanding of the potential relationship between complement, aging, and aging-related diseases will provide molecular targets for treating aging, while focusing on the balance of complement in during treatment. Inhibition of a single component does not result in a good outcome. In this review, we discussed the research progress and effects of complement in aging and aging-related diseases.
补体系统是免疫系统的一部分，由多种具有防御病原体和免疫调节等生物学功能的补体成分组成。补体系统有三种激活途径：经典途径、凝集素途径和替代途径。越来越多的证据表明，补体系统在衰老中起作用。补体在炎症过程、代谢、细胞凋亡、线粒体功能和 Wnt 信号通路中发挥作用。此外，补体系统在与衰老相关的疾病中也发挥着重要作用，包括阿尔茨海默病、年龄相关性黄斑变性和骨关节炎。然而，补体对衰老和衰老相关疾病的影响尚不清楚。因此，更好地了解补体、衰老和衰老相关疾病之间的潜在关系，将为治疗衰老提供分子靶点，同时关注治疗过程中补体的平衡。抑制单个成分并不能产生良好的结果。在这篇综述中，我们讨论了补体在衰老和衰老相关疾病中的研究进展和作用。
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