Hackney Diabetes Centre, Homerton Healthcare NHS Foundation Trust, London E9 6SR, UK.
Endocrinology Department, Barts Health NHS Trust, London E1 1BB, UK.
Nutrients. 2022 Jul 30;14(15):3146. doi: 10.3390/nu14153146.
(1) Background: Formula low energy diets (LED) are effective at inducing weight loss and type 2 diabetes (T2DM) remission. However, the effect of LED programmes in ethnic minority groups in the UK is unknown. (2) Methods: A service-evaluation was undertaken of a group-based LED, total diet replacement (TDR) programme in London, UK. The programme included: a 12-week TDR phase, 9-week food reintroduction and a 31-week weight maintenance phase and was delivered by a diabetes multi-disciplinary team. (3) Results: Between November 2018 and March 2020, 216 individuals were referred, 37 commenced the programme, with 29 completing (78%). The majority were of Black British (20%) ethnicity with a mean (SD) age of 50.4 (10.5) years, a body mass index of 34.4 (4.4) kg/m and a T2DM duration of 4.2 (3.6) years. At 12 months, 65.7% achieved T2DM remission, with a mean bodyweight loss of 11.6 (8.9) kg. Completers lost 15.8 (5.3) kg, with 31.4% of participants achieving ≥15 kg weight loss. Quality of life measures showed significant improvements. (4) Conclusions: This service evaluation shows for the first time in the UK that a group-based formula LED programme can be effective in achieving T2DM remission and weight loss in an ethnical diverse population.
（1）背景：配方低能量饮食（LED）在诱导体重减轻和 2 型糖尿病（T2DM）缓解方面非常有效。然而，英国少数民族群体中 LED 方案的效果尚不清楚。（2）方法：对英国伦敦的一种基于小组的 LED（全饮食替代 TDR）方案进行了服务评估。该方案包括：12 周的 TDR 阶段、9 周的食物重新引入和 31 周的体重维持阶段，由糖尿病多学科团队提供。（3）结果：2018 年 11 月至 2020 年 3 月期间，有 216 人被转介，37 人开始参加该方案，其中 29 人完成（78%）。大多数人是英国黑人（20%），平均年龄（标准差）为 50.4（10.5）岁，体重指数为 34.4（4.4）kg/m，T2DM 持续时间为 4.2（3.6）年。在 12 个月时，65.7%的人达到 T2DM 缓解，平均体重减轻 11.6（8.9）kg。完成者体重减轻 15.8（5.3）kg，其中 31.4%的参与者体重减轻≥15kg。生活质量指标显示出显著改善。（4）结论：这项服务评估首次表明，基于小组的配方 LED 方案在一个种族多样化的人群中可以有效地实现 T2DM 缓解和体重减轻。
