Cespedes Jhoan F, Arévalo-Alquichire Said, Diaz Luis E, Valero Manuel F
Energy, Materials and Environmental Group, GEMA, Faculty of Engineering, Universidad de La Sabana, Chía 140013, Colombia.
Master Program in Design and Management Process, Faculty of Engineering, Universidad de La Sabana, Chía 140013, Colombia.
Polymers (Basel). 2022 Aug 4;14(15):3184. doi: 10.3390/polym14153184.
Improvements in the antithrombogenicity activity of biomaterials for cardiovascular applications are necessary to meet the demand for vascular grafts in the world. Zwitterionic compounds tend to be used due to their anti-fouling properties, which reduce platelet adhesions and protein absorptions. Therefore, in this research, potato starch (AL-N) and zwitterionic starch (AL-Z) (obtained by Williamson etherification) were included as fillers in polyurethane (PU) matrices from polycaprolactone diol (PCL), polyethylene glycol (PEG), pentaerythritol (PE) and isophorone diisocyanate (IPDI) in order to study their effect in terms of their physicochemical, mechanical and thermal properties. We conducted our evaluation using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), contact angle analysis, swelling behavior, thermogravimetric analysis (TGA), tensile/strain analysis, scanning electron microscopy equipped with energy dispersive X-ray spectroscopy (SEM-EDS), dynamic mechanic analysis (DMA), differential scanning calorimetry (DSC), and X-ray diffraction (XRD). The results showed that AL-N and AL-Z modified these properties, where AL-N improved tensile strength, and AL-Z increased the hydrophilicity of polyurethanes matrices; additionally, AL-N had interactions with the soft segments, and AL-Z had interactions with the hard segments. Finally, both fillers reduced the degree of crystallinity and did not affect the thermal stability of polyurethanes.
为满足全球对血管移植物的需求，改善用于心血管应用的生物材料的抗血栓形成活性十分必要。两性离子化合物因其防污性能而常被使用，这种性能可减少血小板黏附和蛋白质吸附。因此，在本研究中，将马铃薯淀粉（AL-N）和两性离子淀粉（通过威廉姆森醚化获得的AL-Z）作为填料加入到由聚己内酯二醇（PCL）、聚乙二醇（PEG）、季戊四醇（PE）和异佛尔酮二异氰酸酯（IPDI）制成的聚氨酯（PU）基质中，以研究它们在物理化学、机械和热性能方面的影响。我们使用衰减全反射傅里叶变换红外光谱（ATR-FTIR）、接触角分析、溶胀行为、热重分析（TGA）、拉伸/应变分析、配备能量色散X射线光谱的扫描电子显微镜（SEM-EDS）、动态力学分析（DMA）、差示扫描量热法（DSC）和X射线衍射（XRD）进行了评估。结果表明，AL-N和AL-Z改变了这些性能，其中AL-N提高了拉伸强度，而AL-Z增加了聚氨酯基质的亲水性；此外，AL-N与软段有相互作用，AL-Z与硬段有相互作用。最后，两种填料都降低了结晶度，且不影响聚氨酯的热稳定性。
