三碘甲状腺原氨酸（T3）对GH3细胞细胞膜直接作用的证据：一种电生理学方法。
Evidence of a direct action of triiodothyronine (T3) on the cell membrane of GH3 cells: an electrophysiological approach.
作者信息
du Pont J S, Israel J M
出版信息
Experientia. 1987 Jun 15;43(6):596-8. doi: 10.1007/BF02126342.
PMID:3595791
Abstract
Electrophysiological experiments demonstrate that triiodothyronine (T3) exerts a direct effect on the membrane of a strain of cultured rat pituitary tumor cells, GH3/B6. These cells respond to pressure application of T3 (2-5 nl, concentration 1 X 10(-10) M) with an increase in the membrane resistance (Rm) and a hyperpolarization. Spontaneously firing cells become silent.
摘要
电生理实验表明，三碘甲状腺原氨酸（T3）对培养的大鼠垂体肿瘤细胞系GH3/B6的细胞膜有直接作用。这些细胞在施加T3（2 - 5 nl，浓度1×10⁻¹⁰ M）时，膜电阻（Rm）增加并出现超极化。自发放电的细胞变得静止。
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