Moraghebi Mahta, Negahi Ahmad Agha, Bazireh Homa, Abbasi Hossein, Ahmadi Mohsen, Sarikhani Zohreh, Mousavi Pegah
Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Department of Internal Medicine, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Bioinform Biol Insights. 2022 Aug 4;16:11779322221116322. doi: 10.1177/11779322221116322. eCollection 2022.
Multiple sclerosis (MS) is a central nervous disorder caused by several factors. Studies have recently shown that non-coding RNA such as miRNA could participate in MS initiation, progression, and active lesion. This study aims to theoretically analyze the potential impact of single-nucleotide polymorphisms (SNPs) on mir-21 and mir-146a/b, which has been previously demonstrated as MS microRNA signature. To fulfill this purpose, the SNPs were investigated for functionality through several online tools, including miRNA-SNP, SNP2-TFBS, RBP-Var, and RNAfold. Furthermore, SNPs of miR-21 and miR-146a/b that exist in pre-miRNA, mature miRNA, and promoter area were extracted; moreover, miRNA and RNA-binding protein interactions were analyzed. This article presented a list of validated SNPs that could affect the expression or function of miR-21 and miR-146a/b for the future practical study of MS and active lesions.
多发性硬化症（MS）是一种由多种因素引起的中枢神经系统疾病。最近的研究表明，诸如miRNA等非编码RNA可能参与MS的发病、进展以及活动性病灶的形成。本研究旨在从理论上分析单核苷酸多态性（SNP）对mir-21和mir-146a/b的潜在影响，这两种miRNA先前已被证明是MS的miRNA特征。为实现这一目的，通过多种在线工具对SNP的功能进行了研究，包括miRNA-SNP、SNP2-TFBS、RBP-Var和RNAfold。此外，提取了存在于前体miRNA、成熟miRNA和启动子区域的miR-21和miR-146a/b的SNP；此外，还分析了miRNA与RNA结合蛋白的相互作用。本文列出了一系列经过验证的SNP，这些SNP可能影响miR-21和miR-146a/b的表达或功能，为未来MS及活动性病灶的实际研究提供参考。
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