N-甲基-N-(2-羟乙基或3-羟丙基)-1,3,3-三甲基双环[2.2.1]庚-2-内胺的异烟酸酯、烟酸酯和氯贝酯，具有降胆固醇和降血脂活性。
Isonicotinates, nicotinates and clofibrates of N-methyl-N-(2-hydroxyethyl or 3-hydroxypropyl)--1,3,3-trimethylbicyclo [2.2.1]heptan-2-endo-amine with hypocholesterolemic and hypolipidemic activity.
作者信息
Bondavalli F, Bruno O, Schenone P, Vacca C, De Carlo R, Marmo E
出版信息
Farmaco Sci. 1987 Apr;42(4):251-7. doi: 10.1002/chin.198744207.
PMID:3595837
Abstract
The synthesis of isonicotinic, nicotinic and clofibric esters (III a, b, c) and (IV a, b, c) starting from N-methyl-N-(2-hydroxyethyl or 3-hydroxypropyl)-1,3,3-trimethylbicyclo [2.2.1] heptan-2-endo-amine is described. In general these esters showed a normolipemic activity in rats; in particular, the isonicotinic ester (IV a) showed a hypocholesterolemic activity higher than that of clofibric acid.
摘要
描述了从N-甲基-N-(2-羟乙基或3-羟丙基)-1,3,3-三甲基双环[2.2.1]庚烷-2-内型胺出发合成异烟酸酯、烟酸酯和氯贝酸酯(III a、b、c)以及(IV a、b、c)的方法。一般来说，这些酯在大鼠中表现出降血脂活性；特别是，异烟酸酯(IV a)的降胆固醇活性高于氯贝酸。
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