洛图卡因噻吩类似物的合成与药理评价
Synthesis and pharmacological evaluation of thiophene analogs of lotucaine.
作者信息
Corral C, el-Ashmawy M B, Lissavetzky J, Bravo L, Darias V, Martin D
出版信息
Farmaco Sci. 1987 Apr;42(4):267-75.
PMID:3595838
Abstract
The syntheses of the three possible thiophene analogs of lotucaine, and of other structurally related derivatives, are described. Preliminary data on their local anesthetic as well as antiplatelet aggregation activities are given.
摘要
本文描述了芦图卡因三种可能的噻吩类似物以及其他结构相关衍生物的合成方法。文中给出了它们局部麻醉以及抗血小板聚集活性的初步数据。
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