Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.
Front Immunol. 2022 Jul 25;13:936547. doi: 10.3389/fimmu.2022.936547. eCollection 2022.
Sepsis is an unsolved clinical condition with a substantial mortality rate in the hospital. Despite decades of research, no effective treatments for sepsis exists. The role of adenosine in the pathogenesis of sepsis is discussed in this paper. Adenosine is an essential endogenous molecule that activates the A1, A2a, A2b, and A3 adenosine receptors to regulate tissue function. These receptors are found on a wide range of immune cells and bind adenosine, which helps to control the immune response to inflammation. The adenosine receptors have many regulatory activities that determine the onset and progression of the disease, which have been discovered the use of animal models. A greater understanding of the role of adenosine in modulating the immune system has sparked hope that an adenosine receptor-targeted treatment may be used one day to treat sepsis.
脓毒症是一种临床难题，其在医院的死亡率相当高。尽管已经进行了数十年的研究，但目前仍没有针对脓毒症的有效治疗方法。本文讨论了腺苷在脓毒症发病机制中的作用。腺苷是一种重要的内源性分子，可通过激活 A1、A2a、A2b 和 A3 腺苷受体来调节组织功能。这些受体存在于广泛的免疫细胞上，并与腺苷结合，有助于控制对炎症的免疫反应。在使用动物模型的情况下，已经发现了腺苷受体的许多调节活性，这些活性决定了疾病的发生和进展。对腺苷在调节免疫系统中的作用有了更深入的了解，这让人们燃起了希望，即有朝一日可以使用靶向腺苷受体的治疗方法来治疗脓毒症。
