纤维蛋白原联合中性粒细胞与淋巴细胞比值在预测胃癌患者预后中的意义
The Significance of Fibrinogen in Combination with the Neutrophil to Lymphocyte Ratio in Predicting the Prognosis of Patients with Gastric Cancer.
作者信息
Li Xinran, Zheng Jiamin, Yan Min, Lu Ye, Pan Xiangtao
机构信息
Department of Hematology and Oncology, Suzhou Medical College of Soochow University, Taicang Hospital Affiliated of Soochow University, Taicang City, People's Republic of China.
出版信息
Cancer Manag Res. 2022 Aug 4;14:2313-2321. doi: 10.2147/CMAR.S374978. eCollection 2022.
OBJECTIVE
To investigate the significance of fibrinogen (Fib) in combination with the neutrophil to lymphocyte ratio (NLR) in predicting the prognosis of patients with gastric cancer.
METHODS
The preoperative peripheral blood-related indicators of 281 gastric cancer patients were reviewed retrospectively, and the differences in relationship indicators between the survival and death groups were compared and analyzed. The COX regression analysis and Kaplan-Meier Curve (K-M) were used to assess the prognostic significance of Fib combined with NLR in patients with gastric cancer.
RESULTS
① The difference between the survival and death groups of patients with gastric cancer was statistically significant in the high and low Fib and NLR levels ( =6.868 and 17.051, respectively, all <0.01).② The correlation between Fib and NLR was remarkable (=0.266, =0.000).③ The F-NLR classifications showed statistically significant difference between the survival and death groups for gastric cancer patients ( =20.200, =0.000).④ Except for Fib and the middle/low classification of F-NLR, which was <0.05, and the rest were all <0.01. There was a substantial statistical difference between F-NLR classifications, Fib and NLR.⑤ F-NLR was found to be a predictive factor of death in patients with gastric cancer in COX regression analysis (=0.000).⑥Patients with F-NLR scores of "0", "1" and "2" had 5-year survival rates of 92.6%, 64.0% and 47.2%, respectively, and 3-year survival rates of 92.6%, 74.3% and 51.9%, respectively (all =0.000).
CONCLUSION
The combination of Fib and NLR (F-NLR) improves the accuracy of prognosis in patients with gastric cancer.
目的
探讨纤维蛋白原（Fib）联合中性粒细胞与淋巴细胞比值（NLR）对胃癌患者预后的预测意义。
方法
回顾性分析281例胃癌患者术前外周血相关指标，比较分析生存组与死亡组相关指标的差异。采用COX回归分析和Kaplan-Meier曲线（K-M）评估Fib联合NLR对胃癌患者的预后意义。
结果
①胃癌患者生存组与死亡组Fib和NLR高低水平差异有统计学意义（分别为=6.868和17.051，均<0.01）。②Fib与NLR之间相关性显著（=0.266，=0.000）。③F-NLR分级在胃癌患者生存组与死亡组间差异有统计学意义（=20.200，=0.000）。④除Fib及F-NLR中/低分级<0.05外，其余均<0.01。F-NLR分级、Fib和NLR之间存在显著统计学差异。⑤COX回归分析显示F-NLR是胃癌患者死亡的预测因素（=0.000）。⑥F-NLR评分为“0”“1”“2”的患者5年生存率分别为92.6%、64.0%和47.2%，3年生存率分别为92.6%、74.3%和51.9%（均=0.000）。
结论
Fib与NLR联合（F-NLR）可提高胃癌患者预后的预测准确性。
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