Mao Mengchai, Chen Guifang, Feng Kun, Xu Dongsheng, Hua Xuyun, Shan Chunlei, Liu Pozi
Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
YuQuan Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Front Neurosci. 2022 Jul 26;16:946543. doi: 10.3389/fnins.2022.946543. eCollection 2022.
Bipolar disorder (BD) is a recurrent chronic mental disorder with a broad profile of functional deficits including disturbed emotional processing and cognitive impairments. The goal of the current study was to further explore the underlying neural mechanism of dysfunction in patients with BD from a comprehensive perspective of both cognition and emotion. Forty-six clinical patients with BD and forty-five healthy controls performed emotion induction task and verbal fluency task (VFT), with frontal activity measured by functional near-infrared spectroscopy (fNIRS). Our results show distinct hemodynamic activity in the prefrontal region during emotional and cognitive processing between patients with BD and healthy controls. Patients with BD exhibit valence-dependent prefrontal cortex (PFC) hemodynamic response to emotional stimuli, with bilateral frontal hypoactivity indicating decreased positive reactivity and left frontal hyperactivity indicating increased negative reactivity. On the other hand, patients with BD showed impaired performance with bilateral frontal hypoactivity during VFT. Taken together, frontal dysfunction of cognition and emotionality in patients with BD probed by fNIRS would be a potential biomarker in clinical assessment.
双相情感障碍（BD）是一种复发性慢性精神障碍，具有广泛的功能缺陷，包括情绪加工紊乱和认知障碍。本研究的目的是从认知和情感的综合角度进一步探索双相情感障碍患者功能障碍的潜在神经机制。46名双相情感障碍临床患者和45名健康对照者进行了情绪诱导任务和言语流畅性任务（VFT），通过功能近红外光谱（fNIRS）测量额叶活动。我们的结果显示，双相情感障碍患者和健康对照者在情绪和认知加工过程中前额叶区域的血液动力学活动存在明显差异。双相情感障碍患者对情绪刺激表现出前额叶皮层（PFC）与效价相关的血液动力学反应，双侧额叶活动减退表明正性反应性降低，左侧额叶活动亢进表明负性反应性增加。另一方面，双相情感障碍患者在VFT期间表现受损，双侧额叶活动减退。综上所述，通过fNIRS检测到的双相情感障碍患者认知和情绪方面的额叶功能障碍可能是临床评估中的一个潜在生物标志物。
