虹膜睫状体黑色素瘤的人工晶状体和晶状体囊膜播散：2例临床及组织病理学特征
Intraocular Lens and Lens Capsule Spread of Iridociliary Melanoma: Clinical and Histopathologic Features of 2 Cases.
作者信息
Azarcon Corrina P, Wells Jill R, Aaberg Thomas, Grossniklaus Hans E
机构信息
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Retina Specialists of Michigan, Grand Rapids, Michigan, USA.
出版信息
Ocul Oncol Pathol. 2022 Jun;8(2):105-109. doi: 10.1159/000524052. Epub 2022 Mar 28.
PURPOSE
The aim of this study was to describe 2 patients with intraocular lens (IOL) and lens capsule spread of iridociliary melanoma.
METHODS
Two pseudophakic patients with iridociliary body melanoma that spread onto the surface of their IOL and remaining lens capsule were included. Their eyes were enucleated and the histopathologic features were evaluated.
RESULTS
Case 1 was an 82-year-old woman with diffuse primary iridociliary melanoma affecting the iris, lens capsule, IOL surface, and ciliary body. Case 2 was a 68-year-old female who developed melanoma recurrence in the anterior segment after plaque brachytherapy for iridociliary melanoma. The melanoma in both cases grew as a pigmented membrane onto the surface of the IOL.
CONCLUSIONS
IOL and lens capsule spread of iridociliary melanoma can occur primarily or develop secondarily after plaque brachytherapy of a pseudophakic eye. Since the extent of the melanoma may be uncertain and there is a high likelihood of glaucoma, enucleation is a reasonable option.
目的
本研究旨在描述2例虹膜睫状体黑色素瘤出现人工晶状体（IOL）及晶状体囊膜播散的患者。
方法
纳入2例患有虹膜睫状体黑色素瘤且肿瘤播散至其IOL表面及剩余晶状体囊膜的人工晶状体植入术后患者。对其眼球进行摘除并评估组织病理学特征。
结果
病例1为一名82岁女性，患有弥漫性原发性虹膜睫状体黑色素瘤，累及虹膜、晶状体囊膜、IOL表面及睫状体。病例2为一名68岁女性，其在接受虹膜睫状体黑色素瘤敷贴近距离放疗后在前房出现黑色素瘤复发。两例患者的黑色素瘤均以色素膜的形式生长于IOL表面。
结论
虹膜睫状体黑色素瘤的IOL及晶状体囊膜播散可原发出现，或在人工晶状体植入术后眼的敷贴近距离放疗后继发出现。由于黑色素瘤的范围可能不确定且青光眼的发生可能性高，眼球摘除是一种合理的选择。
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