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该系统的抑郁症遗传学及其躯体和精神共病。

The system's genetics of depression and its somatic and mental comorbidities.

作者信息

Kalinichenko Liubov S, Kornhuber Johannes, Müller Christian P

机构信息

Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.

Centre for Drug Research, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.

出版信息

Transl Neurosci. 2022 Jul 26;13(1):198-200. doi: 10.1515/tnsci-2022-0229. eCollection 2022 Jan 1.

Abstract

Depression is a common mood disorder characterised by high comorbidity with other mental and somatic diseases. New studies reveal a shared genetic base for mental core symptoms and somatic comorbidities. Functional analyses showed multiple brain-body pathways involved. This may help considering new therapeutic approaches for depression as a system's disorder.

摘要

抑郁症是一种常见的情绪障碍,其特征是与其他精神和躯体疾病高度共病。新的研究揭示了精神核心症状和躯体共病存在共同的遗传基础。功能分析表明涉及多个脑-身通路。这可能有助于将抑郁症视为一种系统性疾病来考虑新的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0fd/9328026/a7e207071281/j_tnsci-2022-0229-fig001.jpg

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