贝司他汀和亮抑蛋白酶肽在体内诱导大鼠肝脏中酸溶性肽积累的作用方式以及积累肽的特性。贝司他汀和亮抑蛋白酶肽敏感蛋白酶在体内蛋白质降解途径中的重要作用。
Mode of action of bestatin and leupeptin to induce the accumulation of acid soluble peptides in rat liver in vivo and the properties of the accumulated peptides. The important role of bestatin- and leupeptin-sensitive proteases in the protein degradation pathway in vivo.
作者信息
Takahashi S, Kato H, Takahashi A, Noguchi T, Naito H
出版信息
Int J Biochem. 1987;19(5):401-12. doi: 10.1016/0020-711x(87)90060-7.
PMID:3595989
Abstract
The chemical properties of acid soluble peptides accumulated in liver or excreted into urine after administration of bestatin or leupeptin to rats were investigated extensively. At the same time, the effects of glucagon on the bestatin-induced accumulation of acid soluble peptides were studied. The results show the important role of bestatin- and leupeptin-sensitive proteases in the degradation pathway of intracellular proteins in vivo.
摘要
对给大鼠注射贝抑素或亮抑肽素后在肝脏中积累或排泄到尿液中的酸溶性肽的化学性质进行了广泛研究。同时，研究了胰高血糖素对贝抑素诱导的酸溶性肽积累的影响。结果表明，贝抑素和亮抑肽素敏感的蛋白酶在体内细胞内蛋白质降解途径中起重要作用。
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