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Degradation of endogenous proteins and internalized asialofetuin in primary cultured hepatocytes of rats.

作者信息

Kato H, Takahashi S, Takenaka A, Funabiki R, Noguchi T, Naito H

机构信息

Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo, Japan.

出版信息

Int J Biochem. 1989;21(5):483-95. doi: 10.1016/0020-711x(89)90128-6.

DOI:10.1016/0020-711x(89)90128-6
PMID:2474466
Abstract
  1. The effects of various metabolic and enzyme inhibitors on the degradation of endogenous proteins and internalized asialofetuin were examined in the primary cultured hepatocytes of rats. 2. The results showed the important physiological role of bestatin-sensitive aminopeptidases in the degradation of endogenous and internalized proteins as well as in the degradation of both long- and short-lived proteins.
摘要

相似文献

1
Degradation of endogenous proteins and internalized asialofetuin in primary cultured hepatocytes of rats.
Int J Biochem. 1989;21(5):483-95. doi: 10.1016/0020-711x(89)90128-6.
2
Metabolism of asialoglycoproteins in cultured rat hepatocytes: evidence for receptor mediated uptake and degradation which is not feed-back regulated.
Int J Biochem. 1983;15(6):827-33. doi: 10.1016/0020-711x(83)90154-4.
3
Effects of lysosomal inhibitors on 125I-insulin and 125I-asialofetuin degradation by the isolated, perfused rat liver and isolated rat hepatocytes.溶酶体抑制剂对分离的灌注大鼠肝脏和分离的大鼠肝细胞降解125I-胰岛素及125I-去唾液酸胎球蛋白的影响。
Diabetes. 1985 May;34(5):446-51. doi: 10.2337/diab.34.5.446.
4
Protein catabolism in cultures of hepatocytes derived from mice of various ages.不同年龄小鼠来源的肝细胞培养物中的蛋白质分解代谢
Mech Ageing Dev. 1982 May;19(1):85-94. doi: 10.1016/0047-6374(82)90053-7.
5
Effects of amino acids and amino acid analogues on lysosomal protein degradation in isolated rat hepatocytes.
Acta Biol Med Ger. 1981;40(10-11):1603-12.
6
Role of microtubuli in the lysosomal degradation of endogenous and exogenous protein in isolated rat hepatocytes.微管在分离的大鼠肝细胞内源性和外源性蛋白质溶酶体降解中的作用。
Hoppe Seylers Z Physiol Chem. 1981 May;362(5):549-56. doi: 10.1515/bchm2.1981.362.1.549.
7
The effect of leupeptin on intracellular digestion of asialofetuin in rat hepatocytes.亮抑酶肽对大鼠肝细胞中去唾液酸胎球蛋白细胞内消化的影响。
Exp Cell Res. 1981 Jul;134(1):207-17. doi: 10.1016/0014-4827(81)90478-x.
8
Uptake, intracellular transport, and degradation of polyethylene glycol-modified asialofetuin in hepatocytes.
J Biol Chem. 1992 Nov 15;267(32):22987-93.
9
Vanadate inhibits protein degradation in isolated rat hepatocytes.钒酸盐可抑制离体大鼠肝细胞中的蛋白质降解。
J Biol Chem. 1981 Aug 10;256(15):7699-701.
10
Effect of leupeptin on the intracellular degradation of asialofetuin in isolated rat hepatocytes.亮抑酶肽对离体大鼠肝细胞中去唾液酸胎球蛋白细胞内降解的影响。
Acta Biol Med Ger. 1981;40(10-11):1599-602.

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