Outpatient Department of Hebei Armed Police Corps Hospital, Shijiazhuang, Hebei, P.R. China.
Department of General Surgery, The Fourth People's Hospital of Hengshui, Hengshui, Hebei, P.R. China.
Medicine (Baltimore). 2022 Aug 12;101(32):e29990. doi: 10.1097/MD.0000000000029990.
This study was a systematic review comparing the clinical outcomes of using the nonirradiated and irradiated allograft for anterior cruciate ligament (ACL) reconstruction.
A comprehensive literature search was conducted using multiple databases, including Medline, Embase, and Cochrane. All databases were searched from the earliest records through August 2019 using the following Boolean operators: irradiated AND nonirradiated AND ACL AND allograft. All prospective and retrospective controlled trials were retrieved that directly compared physical examination and knee function scores and patient-rated outcomes between the nonirradiated and irradiated allograft for ACL reconstruction.
Three prospective and 2 retrospective articles were identified by the search, and the findings suggested that the nonirradiated allografts were superior to the irradiated allografts based on improved knee joint functional scores and decreased failure rate, even though there was no significantly difference with respect to overall IKDC, range of motion, vertical jump test, and one-leg hop test.
Irradiated allograft should be limited to be used in ACL surgery and further research into new alternative sterilization techniques are needed to avoiding the disease transmission without interference with the biomechanical properties of the grafts.
本研究是一项系统评价，比较了使用未辐照和辐照同种异体移植物进行前交叉韧带（ACL）重建的临床结果。
使用多个数据库（包括 Medline、Embase 和 Cochrane）进行全面的文献检索，使用以下布尔运算符搜索所有数据库，从最早的记录到 2019 年 8 月：辐照和未辐照和 ACL 和同种异体移植物。检索了所有直接比较未辐照和辐照同种异体移植物用于 ACL 重建的体格检查和膝关节功能评分以及患者评定结果的前瞻性和回顾性对照试验。
通过搜索确定了 3 篇前瞻性和 2 篇回顾性文章，研究结果表明，基于改善的膝关节功能评分和降低的失败率，未辐照同种异体移植物优于辐照同种异体移植物，尽管在总体 IKDC、活动范围、垂直跳跃测试和单腿跳跃测试方面没有显著差异。
辐照同种异体移植物应限制用于 ACL 手术，需要进一步研究新的替代消毒技术，以避免疾病传播而不干扰移植物的生物力学特性。
