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基于 CT 图像评价年龄相关的胸腺变化：一项回顾性观察研究。

Evaluation of age-related thymic changes using computed tomography images: A retrospective observational study.

机构信息

Respiratory Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.

Department of Thoracic Surgery, Showa University Fujigaoka Hospital, Yokohama, Japan.

出版信息

Medicine (Baltimore). 2022 Aug 12;101(32):e29950. doi: 10.1097/MD.0000000000029950.

DOI:10.1097/MD.0000000000029950
PMID:35960086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9371532/
Abstract

We aimed to investigate if Computed tomography (CT) attenuation values can help improve the identification of age-related changes in the thymus. We assessed CT images of 405 patients aged 0 to 80 years. We measured the area of the anterior mediastinum at the level of the carina and its average CT attenuation value. We evaluated the thymic area, the ratio of the thymus area to the total thoracic area, and the CT attenuation value. Additionally, we evaluated changes in the thymus area in the 0 to 13-year age group. The area of the thymus decreased from birth to the middle 20s. After the middle 20s, the area tended to increase and plateau till after 50 years of age. The ratio of the thymic area to the thoracic area decreased from age 0 to 20 years, but remained stable after 20 years of age. The CT attenuation values were stable from birth to puberty, decreased after puberty, and were stable again in the late 50s and beyond. The thymus of children showed mass formation, but the shape changed with age. No significant differences in the CT attenuation value were found across underlying conditions for the 0 to 13-year age group. The decrease in the CT attenuation values, observed with advancing age, reflects adipose degeneration of the thymus, indicating that by the late 50s, thymic tissue is replaced completely by adipose tissue. Our data suggest that adipose degeneration of the thymus begins after puberty and advances with age.

摘要

我们旨在研究计算机断层扫描（CT）衰减值是否有助于提高对胸腺与年龄相关变化的识别。我们评估了 405 名 0 至 80 岁患者的 CT 图像。我们测量了隆突水平前纵隔的面积及其平均 CT 衰减值。我们评估了胸腺面积、胸腺面积与总胸面积的比值以及 CT 衰减值。此外，我们还评估了 0 至 13 岁年龄组胸腺面积的变化。胸腺面积从出生到 20 多岁中期逐渐减少。20 多岁后，面积趋于增加并稳定在 50 岁以后。胸腺面积与胸面积的比值从 0 岁到 20 岁逐渐下降，但 20 岁以后保持稳定。CT 衰减值从出生到青春期稳定，青春期后下降，50 多岁后再次稳定。儿童的胸腺呈肿块形成，但形状随年龄变化。0 至 13 岁年龄组的潜在疾病之间，CT 衰减值无显著差异。随着年龄的增长，CT 衰减值的下降反映了胸腺脂肪变性，表明到 50 多岁后期，胸腺组织完全被脂肪组织取代。我们的数据表明，胸腺脂肪变性始于青春期后，并随年龄增长而进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a14/9371532/c343678da1be/medi-101-e29950-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a14/9371532/db91e6550430/medi-101-e29950-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a14/9371532/0c91b45db274/medi-101-e29950-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a14/9371532/545e29b5d0c7/medi-101-e29950-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a14/9371532/7958226a89c4/medi-101-e29950-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a14/9371532/57b8d7f569cf/medi-101-e29950-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a14/9371532/c343678da1be/medi-101-e29950-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a14/9371532/db91e6550430/medi-101-e29950-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a14/9371532/0c91b45db274/medi-101-e29950-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a14/9371532/545e29b5d0c7/medi-101-e29950-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a14/9371532/7958226a89c4/medi-101-e29950-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a14/9371532/57b8d7f569cf/medi-101-e29950-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a14/9371532/c343678da1be/medi-101-e29950-g006.jpg

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