The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People's Republic of China.
Department of Obstetrics and Gynecology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, Zhejiang Province, People's Republic of China.
Medicine (Baltimore). 2022 Aug 12;101(32):e30013. doi: 10.1097/MD.0000000000030013.
Premature ovarian failure (POF), also known as primary ovarian insufficiency (POI), refers to the loss of ovarian function in women after puberty and before the age of 40 characterized by high serum gonadotropins and low estrogen, irregular menstruation, amenorrhea, and decreased fertility. However, the specific pathogenesis of POF is unexplained, and there is no effective therapy for its damaged ovarian tissue structure and reduced reserve function. Mesenchymal stem cells (MSCs), with multidirectional differentiation potential and self-renewal ability, as well as the cytokines and exosomes they secrete, have been studied and tested to play an active therapeutic role in a variety of degenerative pathologies, and MSCs are the most widely used stem cells in regenerative medicine. MSCs can reverse POI and enhance ovarian reserve function through differentiation into granulosa cells (GCs), immune regulation, secretion of cytokines and other nutritional factors, reduction of GCs apoptosis, and promotion of GCs regeneration. Many studies have proved that MSCs may have a restorative effect on the structure and fertility of injured ovarian tissues and turn to be a useful clinical approach to the treatment of patients with POF in recent years. We intend to use MSCs-based therapy to completely reverse POI in the future.
卵巢早衰（POF），又称原发性卵巢功能不全（POI），是指青春期后和 40 岁前女性卵巢功能丧失，表现为血清促性腺激素升高和雌激素降低、月经不规则、闭经和生育能力下降。然而，POF 的具体发病机制尚不清楚，对于其受损的卵巢组织结构和储备功能下降也没有有效的治疗方法。间充质干细胞（MSCs）具有多向分化潜能和自我更新能力，以及其分泌的细胞因子和外泌体，已被研究和测试在多种退行性病变中发挥积极的治疗作用，是再生医学中应用最广泛的干细胞。MSCs 可以通过分化为颗粒细胞（GCs）、免疫调节、分泌细胞因子和其他营养因子、减少 GCs 凋亡和促进 GCs 再生，来逆转 POI 并增强卵巢储备功能。许多研究已经证明，MSCs 可能对受损卵巢组织的结构和生育能力具有修复作用，近年来已成为治疗 POF 患者的一种有用的临床方法。我们打算将来用基于 MSCs 的治疗方法来彻底逆转 POF。
