Emayavaramban Balakumar, Chakraborty Priyanka, Dahiya Pardeep, Sundararaju Basker
Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India.
Org Lett. 2022 Aug 26;24(33):6219-6223. doi: 10.1021/acs.orglett.2c02545. Epub 2022 Aug 12.
A mild, environmentally benign approach for α-methylation of ketones utilizing methanol as the C1 source under visible light has been developed. The reaction conditions were favorable for a wide range of ketones with both aromatic and aliphatic backbones, allowing for good-to-excellent yields of the respective products. The tentative mechanism is postulated after preliminary mechanistic and kinetic experiments.
已开发出一种温和、环境友好的方法，在可见光下利用甲醇作为C1源对酮进行α-甲基化反应。该反应条件对具有芳香族和脂肪族骨架的多种酮均有利，各自产物的产率良好至优异。在初步的机理和动力学实验后推测了可能的反应机理。
