Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.
Department of Geriatrics, Monash University, Melbourne, Australia.
Metab Brain Dis. 2023 Jan;38(1):17-44. doi: 10.1007/s11011-022-01063-9. Epub 2022 Aug 12.
Alzheimer's disease (AD) is the common type of dementia and is currently incurable. Existing FDA-approved AD drugs may not be effective for everyone, they cannot cure the disease nor stop its progression and their effects diminish over time. Therefore, the present review aimed to explore the role of natural alternatives in the treatment of AD. A systematic search was conducted using Ovid MEDLINE, CINAHL, Cochrane and PubMed databases and reference lists up to November 30, 2021. Only randomized control trials were included and appraised using the National Institute of Health framework. Data analysis showed that herbs like Gingko Biloba, Melissa Officinalis, Salvia officinalis, Ginseng and saffron alone or in combination with curcumin, low-fat diet, NuAD-Trail, and soy lecithin showed significant positive effects on AD. Moreover, combination of natural and pharmaceuticals has far better effects than only allopathic treatment. Thus, different herbal remedies in combination with FDA approved drugs are effective and more promising in treatment of AD.
阿尔茨海默病（AD）是最常见的痴呆症类型，目前无法治愈。现有的美国食品药品监督管理局（FDA）批准的 AD 药物可能并非对所有人都有效，它们既不能治愈这种疾病，也不能阻止其进展，而且随着时间的推移，其效果会逐渐减弱。因此，本综述旨在探讨天然替代品在 AD 治疗中的作用。使用 Ovid MEDLINE、CINAHL、Cochrane 和 PubMed 数据库以及参考文献列表，对截至 2021 年 11 月 30 日的文献进行了系统检索。仅纳入了随机对照试验，并使用美国国立卫生研究院（National Institute of Health）的框架进行评估。数据分析表明，银杏叶、香蜂草、鼠尾草、人参和藏红花单独或与姜黄素、低脂饮食、NuAD-Trail 和大豆卵磷脂联合使用，对 AD 有显著的积极影响。此外，与仅使用对抗疗法相比，天然药物与药物的联合使用具有更好的效果。因此，不同的草药与 FDA 批准的药物联合使用，在 AD 的治疗中更有效、更有前景。
