Anderson V N, Smith G K
Dev Psychobiol. 1987 May;20(3):245-59. doi: 10.1002/dev.420200304.
Rat pups were implanted with intragastric catheters and reared in isolation from their dams and siblings from 3 to 18 days postnatally. They were kept in 12:12 LD or DL, constant light, or constant darkness and were fed with one of three feeding schedules: equal amounts of food delivered during the light and dark periods, 65.3% of the food delivered during the light period, or 65.3% of the food delivered during the dark period. At 18 days postnatally the body, spleen, and kidney weights of all isolated pups did not differ from those of their mother-reared littermates. The isolated pups had smaller cerebellums and forebrains and heavier livers than mother-reared pups. Heavier body and spleen weights and smaller livers were observed in pups with cyclic feeding. Heavier body and forebrain weights were associated with a predominantly diurnal feeding schedule--the schedule which most closely approximated the natural nursing rhythm. Isolated pups opened their eyes sooner than mother-reared littermates. These results suggest that interactions between feeding and light cycles may influence growth and development.
将新生大鼠幼崽植入胃内导管，并在出生后3至18天与母鼠和同胞隔离开来饲养。它们被置于12:12的明暗周期、持续光照或持续黑暗环境中，并按照三种喂食方案之一进行喂养：在光照期和黑暗期提供等量食物、在光照期提供65.3%的食物、或在黑暗期提供65.3%的食物。在出生后18天，所有隔离饲养的幼崽的体重、脾脏重量和肾脏重量与由母鼠抚养的同窝幼崽没有差异。与由母鼠抚养的幼崽相比，隔离饲养的幼崽的小脑和前脑较小，肝脏较重。在采用循环喂食的幼崽中观察到体重和脾脏重量较重，肝脏较小。体重和前脑重量较重与主要在白天喂食的方案有关——该方案最接近自然哺乳节奏。隔离饲养的幼崽比由母鼠抚养的同窝幼崽睁眼更早。这些结果表明，喂食和光照周期之间的相互作用可能会影响生长发育。
