Nishioka N S, Levins P C, Murray S C, Parrish J A, Anderson R R
Gastroenterology. 1987 Aug;93(2):250-5. doi: 10.1016/0016-5085(87)91010-9.
The feasibility of using lasers to fragment biliary calculi was examined in vitro. Flashlamp-pumped tunable dye lasers were coupled to small-diameter flexible quartz fibers that were placed in direct contact with biliary calculi. The minimum laser energy necessary to damage a calculus was measured for wavelengths between 450 and 700 nm and for pulse durations between 0.8 and 360 microseconds. This threshold energy increased with increasing wavelength but was not significantly affected by pulse duration. Cholesterol stones had uniformly higher thresholds than pigmented ones. When a repetitively pulsed laser was used, complete fragmentation required fewer than 500 pulses and fragments were predominantly less than 2 mm. The pulsed dye laser can effectively fragment biliary calculi when transmitted through a small-diameter quartz fiber and may be useful as a tool for fragmenting retained common duct stones.
在体外研究了使用激光破碎胆石的可行性。闪光灯泵浦可调谐染料激光器与小直径柔性石英纤维相连，这些纤维直接与胆石接触。测量了波长在450至700纳米之间以及脉冲持续时间在0.8至360微秒之间时损坏结石所需的最小激光能量。该阈值能量随波长增加而增加，但不受脉冲持续时间的显著影响。胆固醇结石的阈值始终高于色素结石。当使用重复脉冲激光时，完全破碎所需的脉冲少于500个，且碎片主要小于2毫米。脉冲染料激光通过小直径石英纤维传输时可有效破碎胆石，可能作为破碎胆总管残留结石的工具。
