Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA.
Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA
J Immunol. 2022 Aug 15;209(4):645-653. doi: 10.4049/jimmunol.2200273.
Obesity is considered the primary environmental factor associated with morbidity and severity of wide-ranging inflammatory disorders. The molecular mechanism linking high-fat or cholesterol diet to imbalances in immune responses, beyond the increased production of generic inflammatory factors, is just beginning to emerge. Diet cholesterol by-products are now known to regulate function and migration of diverse immune cell subsets in tissues. The hydroxylated metabolites of cholesterol oxysterols as central regulators of immune cell positioning in lymphoid and mucocutaneous tissues is the focus of this review. Dedicated immunocyte cell surface receptors sense spatially distributed oxysterol tissue depots to tune cell metabolism and function, to achieve the "right place at the right time" axiom of efficient tissue immunity.
肥胖被认为是与广泛炎症性疾病的发病率和严重程度相关的主要环境因素。高脂肪或胆固醇饮食与免疫反应失衡之间的分子机制，除了增加通用炎症因子的产生之外，才刚刚开始显现。现在已知饮食胆固醇的副产物可以调节组织中不同免疫细胞亚群的功能和迁移。胆固醇氧化甾醇的羟基化代谢物作为淋巴样和黏膜组织中免疫细胞定位的中枢调节剂，是本综述的重点。专门的免疫细胞表面受体感知空间分布的氧化甾醇组织库，以调节细胞代谢和功能，实现有效的组织免疫的“在正确的时间出现在正确的位置”原则。
