Emergency Department, Neurology Unit, Guglielmo da Saliceto Hospital, Via Giuseppe Taverna 39, 29121, Piacenza, Italy.
Section of Biostatistics, Department of Health Sciences, University of Genova, Genoa, Italy.
Neurol Sci. 2022 Dec;43(12):6657-6659. doi: 10.1007/s10072-022-06333-z. Epub 2022 Aug 13.
The visual-well aerated lung (V-WAL) is a score for the visual quantification of the well aerated lung on CT scan in COVID-19 patients and its value at admission seems to predict future COVID-19 severity. The aim of the present study was to analyze the association between V-WAL and risk factors for severe COVID-19 evolution in people with multiple sclerosis.
This is an observational retrospective study, including people with multiple sclerosis and concomitant COVID-19, who were investigated with a lung CT scan at Hospital admission. The association of V-WAL with age, sex, EDSS, comorbidities, recent steroid use, and treatment (anti-CD20 vs other) was assessed by a multivariate linear regression model.
In this observational retrospective study, the only factor that was significantly associated to a lower V-WAL at multivariable analysis was an increasing level of the EDSS (R = 0.41, p = 0.001), with an average decrease of 8% of V-WAL for each additional EDSS point.
This analysis shows that a high EDSS level is the main factor associated to the severity of lung involvement in a group of people with multiple sclerosis who were hospitalized for Covid-19.
视觉气腔肺（V-WAL）是一种用于评估 COVID-19 患者 CT 扫描上气腔肺的视觉量化评分，其入院时的分值似乎可以预测 COVID-19 的严重程度。本研究的目的是分析 V-WAL 与多发性硬化症患者发生严重 COVID-19 演变的危险因素之间的关联。
这是一项观察性回顾性研究，纳入了同时患有 COVID-19 和多发性硬化症的患者，他们在入院时接受了肺部 CT 扫描检查。通过多元线性回归模型评估 V-WAL 与年龄、性别、EDSS、合并症、近期类固醇使用以及治疗（抗 CD20 与其他）之间的相关性。
在这项观察性回顾性研究中，多变量分析显示，唯一与 V-WAL 降低显著相关的因素是 EDSS 水平升高（R=0.41，p=0.001），EDSS 每增加 1 分，V-WAL 平均降低 8%。
本分析表明，在因 COVID-19 住院的一组多发性硬化症患者中，EDSS 水平较高是与肺部受累严重程度相关的主要因素。
