Zalevsky Zeev, Elkabetz Shimon, Rudnitsky Arkady, Herman Oran, Meiri Amihai, Shahmoon Asaf
Faculty of Engineering, Bar Ilan University, 5290002, Ramat-Gan, Israel.
Zsquare Medical Ltd, 43 Hasivim St., 4959501, Petah Tikva, Israel.
Surg Endosc. 2023 Apr;37(4):3162-3172. doi: 10.1007/s00464-022-09511-4. Epub 2022 Aug 12.
The main objective is related to the capability of integrating into minimally invasive and ultra-thin disposable micro-endoscopic tool, a modality of realizing high-resolution imaging through scattering medium such as blood while performing medical procedure. In this research we aim for the first time to present a time-multiplexing super-resolving approach exhibiting enhanced focus sensitivity, generated by 3D spatial filtering, for significant contrast increase in images collected through scattering medium.
Our innovative method of imaging through scattering media provides imaging of only one specific object plane in scattering medium's volume while suppressing the noise coming from all other planes. The method should be assisted with axial scanning to perform imaging of the entire 3D object's volume. In our developed optical system noise suppression is achieved by 3D spatial filtering approach while more than an order of magnitude of suppression is experimentally demonstrated. The sensitivity to defocus and noise suppression is dramatically enhanced by placing an array of micro-lenses combined with pinholes raster positioned between two modules of telecentric lenses.
We present our novel conceptual designs for the enhanced signal-to-noise ratio (SNR) when imaging through scattering medium and present preliminary experimental results demonstrating both quality imaging performed on resolution bars target as well as SNR quantified results in which SNR enhancement of more than one order of magnitude was obtained.
In this paper, to the best of our knowledge, we present the first ever design of time-multiplexing-based approach for super-resolved imaging through scattering medium. The approach includes a time-multiplexing optical design significantly increasing the depth of focus sensitivity and after performing axial scanning yielding a significant enhancement of the SNR of the 3D object that is being imaged through the scattering medium. Right after the contrast (the SNR) enhancement we scan the object with the projected array of spots (raster) and map it continuously and with high imaging resolution.
主要目标是将其集成到微创超薄一次性微型内窥镜工具中的能力，这是一种在进行医疗程序时通过诸如血液等散射介质实现高分辨率成像的方式。在本研究中，我们首次旨在提出一种时间复用超分辨方法，该方法通过三维空间滤波产生增强的焦点灵敏度，以显著提高通过散射介质采集的图像的对比度。
我们通过散射介质成像的创新方法在散射介质体积中仅对一个特定物平面进行成像，同时抑制来自所有其他平面的噪声。该方法应辅以轴向扫描以对整个三维物体体积进行成像。在我们开发的光学系统中，通过三维空间滤波方法实现噪声抑制，并且实验证明了超过一个数量级的抑制效果。通过在两个远心透镜模块之间放置微透镜阵列与针孔光栅相结合，显著提高了对散焦的灵敏度和噪声抑制能力。
我们展示了通过散射介质成像时提高信噪比（SNR）的新颖概念设计，并展示了初步实验结果，这些结果表明在分辨率条目标上进行了高质量成像，以及SNR量化结果，其中获得了超过一个数量级的SNR增强。
在本文中，据我们所知，我们首次提出了基于时间复用的通过散射介质进行超分辨成像的方法设计。该方法包括一种时间复用光学设计，可显著提高焦点灵敏度深度，在进行轴向扫描后，通过散射介质成像的三维物体的SNR得到显著增强。在对比度（SNR）增强之后，我们立即用投影的点阵列（光栅）扫描物体，并以高成像分辨率连续映射它。
