遗传搭便车与Y性染色体遗传活性降低的进化
Genetic hitchhiking and the evolution of reduced genetic activity of the Y sex chromosome.
作者信息
Rice W R
出版信息
Genetics. 1987 May;116(1):161-7. doi: 10.1093/genetics/116.1.161.
Abstract
A new model for the evolution of reduced genetic activity of the Y sex chromosome is described. The model is based on the process of genetic hitchhiking. It is shown that the Y chromosome can gradually lose its genetic activity due to the fixation of deleterious mutations that are linked with other beneficial genes. Fixation of deleterious Y-linked mutations generates locus-specific selection for dosage tolerance and/or compensation. The hitchhiking effect is most pronounced when operating in combination with an alternative model, Muller's ratchet. It is shown, however, that the genetic hitchhiking mechanism can operate under conditions where Muller's ratchet is ineffective.
摘要
本文描述了一种关于Y性染色体遗传活性降低的进化新模型。该模型基于遗传搭便车过程。研究表明，Y染色体可能会因与其他有益基因连锁的有害突变的固定而逐渐丧失其遗传活性。有害的Y连锁突变的固定会产生针对剂量耐受性和/或补偿的位点特异性选择。当与另一种模型——穆勒棘轮相结合时，遗传搭便车效应最为明显。然而，研究表明，遗传搭便车机制可以在穆勒棘轮无效的条件下发挥作用。
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