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The primary structure of a peroxisomal fatty acyl-CoA oxidase from the yeast Candida tropicalis pK233.

作者信息

Murray W W, Rachubinski R A

出版信息

Gene. 1987;51(2-3):119-28. doi: 10.1016/0378-1119(87)90300-3.

DOI:10.1016/0378-1119(87)90300-3
PMID:3596241
Abstract

We report the isolation and nucleotide (nt) sequence determination of a gene encoding peroxisomal fatty acyl-CoA oxidase (AOx) from the yeast Candida tropicalis pK233. The AOx gene contains no intervening sequences and has a single open reading frame of 2127 nt encoding a protein of 708 amino acids (aa), not including the initiator methionine. The Mr of the protein is 79,155. Codon utilization in the gene is not random, with 87.4% of the aa specified by 25 principal codons. The principal codons used in the expression of AOx in C. tropicalis are similar to those used in highly expressed genes of Saccharomyces cerevisiae. The AOx protein shows a 94.2% homology with POX4 protein of C. tropicalis. One stretch of 36 aa shows no homology between the two proteins.

摘要

相似文献

1
The primary structure of a peroxisomal fatty acyl-CoA oxidase from the yeast Candida tropicalis pK233.
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2
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引用本文的文献

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Acyl CoA oxidase: from its expression, structure, folding, and import to its role in human health and disease.酰基辅酶 A 氧化酶：从其表达、结构、折叠和导入到在人类健康和疾病中的作用。
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2
Evaluation of acyl coenzyme A oxidase (Aox) isozyme function in the n-alkane-assimilating yeast Yarrowia lipolytica.在正构烷烃同化酵母解脂耶氏酵母中对酰基辅酶A氧化酶（Aox）同工酶功能的评估。
J Bacteriol. 1999 Sep;181(17):5140-8. doi: 10.1128/JB.181.17.5140-5148.1999.
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Peroxisome targeting signal of rat liver acyl-coenzyme A oxidase resides at the carboxy terminus.
大鼠肝脏酰基辅酶A氧化酶的过氧化物酶体靶向信号位于羧基末端。
Mol Cell Biol. 1989 Jan;9(1):83-91. doi: 10.1128/mcb.9.1.83-91.1989.
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Isolation of Candida tropicalis auxotrophic mutants.热带假丝酵母营养缺陷型突变体的分离
Appl Environ Microbiol. 1990 Aug;56(8):2562-4. doi: 10.1128/aem.56.8.2562-2564.1990.
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In vivo import of Candida tropicalis hydratase-dehydrogenase-epimerase into peroxisomes of Candida albicans.
Curr Genet. 1990 Jun;17(6):481-6. doi: 10.1007/BF00313075.
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Determination of Candida tropicalis acyl coenzyme A oxidase isozyme function by sequential gene disruption.通过连续基因敲除确定热带假丝酵母酰基辅酶A氧化酶同工酶的功能
Mol Cell Biol. 1991 Sep;11(9):4333-9. doi: 10.1128/mcb.11.9.4333-4339.1991.