Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar, 125001, Haryana, India.
Cancer Pharmacology Division, CSIR-Institute of Integrative Medicine, Canal Road, Jammu, 180001, India.
Chem Biodivers. 2022 Sep;19(9):e202200560. doi: 10.1002/cbdv.202200560. Epub 2022 Aug 26.
Nineteen heterocyclic chalcones were synthesized from 4-acetyl-5-methylquinolylpyrazole and heteroaryl (imidazole, pyrazole, thiophene, indole and triazole) aldehydes and were screened in vitro using four tumor cell lines for their cytotoxic capability and for antimicrobial activity. The chalcone 5b exhibited the highest activity with IC values 2.14 μM against colon (HCT-116) and 5.0 μM, against prostate (PC-3) cancer cell lines and also displayed good activity against fungal strain (A. niger) with MIC value 9.1 μM. The chalcones 5q and 5p displayed good activity against bacterial strains (S. aureus) having MIC value 2.6 μM and fungal strain (C. albicans) having MIC value 5.4 μM, respectively. The molecular docking outcome revealed that the synthesized heterocyclic chalcones demonstrated hydrogen bond, hydrophobic and electrostatic interactions with their respective biochemical targets.
合成了 19 种杂环查尔酮，它们由 4-乙酰基-5-甲基喹啉基吡唑和杂芳基（咪唑、吡唑、噻吩、吲哚和三唑）醛合成，并在体外使用四种肿瘤细胞系进行了细胞毒性和抗菌活性筛选。查尔酮 5b 对结肠（HCT-116）和前列腺（PC-3）癌细胞系的活性最高，IC 值分别为 2.14 μM 和 5.0 μM，对真菌（黑曲霉）也显示出良好的活性，MIC 值为 9.1 μM。查尔酮 5q 和 5p 对细菌（金黄色葡萄球菌）和真菌（白色念珠菌）的活性分别为 2.6 μM 和 5.4 μM，MIC 值较低。分子对接结果表明，合成的杂环查尔酮与各自的生化靶标表现出氢键、疏水和静电相互作用。
