Infertility and IVF Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Hospital, Petach Tikva 4941492, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Infertility and IVF Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Hospital, Petach Tikva 4941492, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Reprod Biomed Online. 2022 Oct;45(4):696-702. doi: 10.1016/j.rbmo.2022.05.013. Epub 2022 May 28.
Does dual trigger (the co-administration of triptorelin 0.2 mg and recombinant human chorionic gonadotrophin (HCG) [Decapeptyl 0.2 mg + Ovitrelle 250 µg]) versus standard recombinant HCG (Ovitrelle 250 µg) affect embryo quality and morphokinetic parameters?
Morphokinetic parameters and embryo quality of embryos derived from the first gonadotrophin-releasing hormone (GnRH) antagonist IVF/intracytoplasmic sperm injection (ICSI) cycles triggered by dual trigger or standard HCG trigger in women ≤42 years. Outcome measures included time to pronucleus fading (tPNf), cleavage timings (t2-t8), synchrony of the second cycle (s2), duration of the second cycle (cc2) and known implantation data (KID) scoring for embryo quality. Multivariate linear and logistic regression analyses were performed for confounding factors.
A total of 4859 embryos were analysed: 1803 embryos from 267 cycles in the dual trigger group and 3056 embryos from 463 cycles in the HCG trigger group. The groups were similar in patient and treatment characteristics apart from a higher maternal body mass index and lower maturation rate in the dual trigger group. Time to second polar body extrusion was shorter in the dual trigger group. Cleavage timings from zygote to an 8-cell embryo did not differ between the two groups. There was a higher percentage of embryos with an optimal cc2 duration in the HCG group. In multivariate logistic regression models, the trigger type was not a significant factor for cell cycle division parameters.
Overall, there was no significant difference in the morphokinetic parameters or quality of embryos evaluated using a time-lapse monitoring system between embryos derived following dual trigger compared with HCG.
双触发（三苯氧胺 0.2mg 和重组人绒毛膜促性腺激素（HCG）[Decapeptyl 0.2mg+Ovitrelle 250μg]的联合给药）与标准重组 HCG（Ovitrelle 250μg）触发对胚胎质量和形态动力学参数有影响吗？
在年龄≤42 岁的女性中，通过双触发或标准 HCG 触发 GnRH 拮抗剂 IVF/胞浆内精子注射（ICSI）周期获得的胚胎的形态动力学参数和胚胎质量。结局指标包括原核消失时间（tPNf）、卵裂时间（t2-t8）、第二周期同步性（s2）、第二周期持续时间（cc2）和胚胎质量的已知着床数据（KID）评分。对混杂因素进行了多变量线性和逻辑回归分析。
共分析了 4859 个胚胎：双触发组 267 个周期的 1803 个胚胎和 HCG 触发组 463 个周期的 3056 个胚胎。除了双触发组的母体体重指数较高和成熟率较低外，两组患者和治疗特征相似。双触发组第二极体排出时间较短。从受精卵到 8 细胞胚胎的卵裂时间在两组之间没有差异。HCG 组具有最佳 cc2 持续时间的胚胎百分比更高。在多变量逻辑回归模型中，触发类型不是细胞周期分裂参数的显著因素。
总体而言，使用时间 lapse 监测系统评估胚胎的形态动力学参数或质量，双触发与 HCG 相比，没有显著差异。
